Delisi Davide Antonio, Saatloo Maedeh Vakili
Department of pharmacology, Medical University of South Carolina, Charleston, SC.
Department of pharmacology, Medical University of South Carolina, Charleston, SC.
Curr Top Membr. 2023;92:125-150. doi: 10.1016/bs.ctm.2023.09.008. Epub 2023 Nov 10.
Ion channels play a crucial role in cellular signaling, homeostasis, and generation of electrical and chemical signals. Aberrant expression and dysregulation of ion channels have been associated with cancer development and resistance to conventional cancer treatment such as chemotherapy. Several molecular mechanisms have been proposed to explain this phenomenon. Including evasion of apoptosis, decreased drug accumulation in cancer cells, detoxifying and activation of alternative escape pathways such as autophagy. Each of these mechanisms leads to a reduction of the therapeutic efficacy of administered drugs, causing more difficulty in cancer treatment. This review highlights the linkages between ion channels and resistance to chemotherapy. Furthermore, it elaborates their molecular mechanisms and the potential of being therapeutic targets in clinical management.
离子通道在细胞信号传导、体内平衡以及电信号和化学信号的产生中起着至关重要的作用。离子通道的异常表达和失调与癌症的发展以及对化疗等传统癌症治疗的耐药性有关。已经提出了几种分子机制来解释这种现象。包括逃避细胞凋亡、癌细胞中药物积累减少、解毒以及激活自噬等替代逃逸途径。这些机制中的每一种都会导致所给药的治疗效果降低，给癌症治疗带来更大困难。本综述强调了离子通道与化疗耐药性之间的联系。此外，还阐述了它们的分子机制以及在临床管理中作为治疗靶点的潜力。
