Fishman P S
Arch Neurol. 1987 Jan;44(1):98-100. doi: 10.1001/archneur.1987.00520130076021.
Since both poliomyelitis and amyotrophic lateral sclerosis affect spinal motor neurons, a relationship between these two diseases has been suggested. Corticospinal tract (CST) degeneration, a prominent aspect of amyotrophic lateral sclerosis, is rarely observed in acute poliomyelitis. Autopsy material from seven patients who had survived long periods after severe paralytic poliomyelitis was examined for evidence of CST degeneration. Although there was severe motor neuron loss and destruction of ventral horn cytoarchitecture, none of the spinal cords showed significant demyelination, fiber loss, or gliosis in the region of the CST. The structural integrity of the CST is maintained for many years after severe motor neuron loss due to poliomyelitis.
由于脊髓灰质炎和肌萎缩侧索硬化症都会影响脊髓运动神经元，因此有人提出这两种疾病之间存在关联。皮质脊髓束（CST）变性是肌萎缩侧索硬化症的一个显著特征，在急性脊髓灰质炎中很少见。对7例严重麻痹性脊髓灰质炎后长期存活患者的尸检材料进行检查，以寻找CST变性的证据。尽管存在严重的运动神经元丧失和腹角细胞结构破坏，但所有脊髓在CST区域均未显示明显的脱髓鞘、纤维丧失或胶质增生。由于脊髓灰质炎导致严重运动神经元丧失后，CST的结构完整性可维持多年。
