Monllor Paloma, Kumar Pratyush, Lloret Mari-Ángeles, Ftara Artemis, Leon Jose-Luis, Lopez Begoña, Cervera-Ferri Ana, Lloret Ana
Department of Physiology, Faculty of Medicine, University of Valencia, INCLIVA, CIBERFES, Spain.
Internal Medicine Department, University Hospital of La Plana, Vila-Real, Spain.
J Alzheimers Dis. 2023;96(4):1399-1409. doi: 10.3233/JAD-230396.
There are several implications of the surge in the incidence of pandemics and epidemics in the last decades. COVID-19 being the most remarkable one, showed the vulnerability of patients with neurodegenerative diseases like Alzheimer's disease (AD). This review studies the pathological interlinks and triggering factors between the two illnesses and proposes a multifactorial pathway of AD causation due to COVID-19. The article evaluates and describes all the postulated hypotheses which explain the etiology and possible pathogenesis of the disease in four domains: Inflammation & Neurobiochemical interactions, Oxidative Stress, Genetic Factors, and Social Isolation. We believe that a probable hypothesis of an underlying cause of AD after COVID-19 infection could be the interplay of all these factors.
在过去几十年里，大流行病和流行病发病率的激增有若干影响。2019冠状病毒病（COVID-19）是最显著的一例，它显示了患有神经退行性疾病如阿尔茨海默病（AD）的患者的脆弱性。本综述研究了这两种疾病之间的病理联系和触发因素，并提出了由COVID-19导致AD的多因素致病途径。本文在炎症与神经生化相互作用、氧化应激、遗传因素和社会隔离这四个领域评估并描述了所有解释该疾病病因和可能发病机制的假设。我们认为，COVID-19感染后AD潜在病因的一个可能假设可能是所有这些因素的相互作用。
