Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Alzheimer's Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China.
Front Immunol. 2023 Feb 9;14:1120495. doi: 10.3389/fimmu.2023.1120495. eCollection 2023.
Alzheimer's disease (AD) and COVID-19 share many common risk factors, such as advanced age, complications, genotype, etc. Epidemiological studies have also confirmed the internal relationship between the two diseases. For example, studies have found that AD patients are more likely to suffer from COVID-19, and after infection with COVID-19, AD also has a much higher risk of death than other chronic diseases, and what's more interesting is that the risk of developing AD in the future is significantly higher after infection with COVID-19. Therefore, this review gives a detailed introduction to the internal relationship between Alzheimer's disease and COVID-19 from the perspectives of epidemiology, susceptibility and mortality. At the same time, we focused on the important role of inflammation and immune responses in promoting the onset and death of AD from COVID-19.
阿尔茨海默病（AD）和 COVID-19 有许多共同的风险因素，如高龄、并发症、基因型等。流行病学研究也证实了这两种疾病之间的内在关系。例如，研究发现 AD 患者更容易感染 COVID-19，而感染 COVID-19 后，AD 的死亡率也比其他慢性疾病高得多，更有趣的是，感染 COVID-19 后，未来患 AD 的风险显著增加。因此，本综述从流行病学、易感性和死亡率等方面详细介绍了 AD 和 COVID-19 之间的内在关系。同时，我们重点关注了炎症和免疫反应在促进 COVID-19 导致 AD 发病和死亡方面的重要作用。
