人体体能与淀粉样蛋白-β：观察性研究的系统评价和荟萃分析。

Physical Performance and Amyloid-β in Humans: A Systematic Review and Meta-Analysis of Observational Studies.

机构信息

Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.

Nuclear Medicine Services, "Virgen de Las Nieves", University Hospital, Granada, Spain.

出版信息

J Alzheimers Dis. 2023;96(4):1427-1439. doi: 10.3233/JAD-230586.

DOI:10.3233/JAD-230586

PMID:38007656

Abstract

BACKGROUND

Accumulation of amyloid-β (Aβ) plaques is one of the main features of Alzheimer's disease (AD). Physical performance has been related to dementia risk and Aβ, and it has been hypothesized as one of the mechanisms leading to greater accumulation of Aβ. Yet, no evidence synthesis has been performed in humans.

OBJECTIVE

To investigate the association of physical performance with Aβ in humans, including Aβ accumulation on brain, and Aβ abnormalities measured in cerebrospinal fluid (CSF) and blood.

METHODS

A systematic review with multilevel meta-analysis was performed from inception to June 16th, 2022. Studies were eligible if they examined the association of physical performance with Aβ levels, including the measure of physical performance as a predictor and the measure of Aβ as an outcome in humans.

RESULTS

7 articles including 2,619 participants were included in the meta-analysis. The results showed that physical performance was not associated with accumulation of Aβ in the brain (ES = 0.01; 95% CI -0.21 to 0.24; I2 = 69.9%), in the CSF (ES = -0.28; 95% CI -0.98 to 0.41; I2 = 91.0%) or in the blood (ES = -0.19; 95% CI -0.61 to 0.24; I2 = 99.75%). Significant heterogeneity was found across the results , which posed challenges in arriving at consistent conclusions; and the limited number of studies hindered the opportunity to conduct a moderation analysis.

CONCLUSIONS

The association between physical performance and Aβ is inconclusive. This uncertainly arises from the limited number of studies, study design limitations, and heterogeneity of measurement approaches. More studies are needed to determine whether physical performance is related to Aβ levels in humans.

摘要

背景

淀粉样蛋白-β（Aβ）斑块的积累是阿尔茨海默病（AD）的主要特征之一。身体表现与痴呆风险和 Aβ 有关，并且有人假设它是导致 Aβ 积累更多的机制之一。然而，尚未在人类中进行证据综合。

目的

研究身体表现与人类 Aβ 的关系，包括大脑中的 Aβ 积累以及脑脊液（CSF）和血液中测量的 Aβ 异常。

方法

从成立到 2022 年 6 月 16 日进行了系统评价和多层次荟萃分析。如果研究检查了身体表现与 Aβ 水平之间的关系，包括身体表现作为预测因素的测量和 Aβ 作为人类结果的测量，则研究符合纳入标准。

结果

纳入了 7 篇文章，共 2619 名参与者，进行了荟萃分析。结果表明，身体表现与大脑中 Aβ 的积累（ES=0.01；95%CI-0.21 至 0.24；I2=69.9%）、CSF 中 Aβ 的积累（ES=-0.28；95%CI-0.98 至 0.41；I2=91.0%）或血液中 Aβ 的积累（ES=-0.19；95%CI-0.61 至 0.24；I2=99.75%）无关。结果存在显著的异质性，这使得得出一致的结论具有挑战性；而且研究数量有限，限制了进行调节分析的机会。