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脐带血中的双酚衍生物与甲状腺激素及潜在暴露源之间的关系。

Bisphenol derivatives in cord blood and association between thyroid hormones and potential exposure sources.

机构信息

Faculty of Medicine, Department of Public Health, Hacettepe University, Ankara, Turkey.

Faculty of Medicine, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.

出版信息

Int J Environ Health Res. 2024 Aug;34(8):3036-3045. doi: 10.1080/09603123.2023.2286016. Epub 2023 Nov 26.

Abstract

Endocrine-disrupting environmental chemicals are a public health concern, particularly fetal exposure to Bisphenol derivatives. This study aimed to assess fetal exposure to Bisphenol derivatives (BPA, BPF, and BPS) by measuring their levels in cord blood and investigating their association with plastic material used in daily life as well as cord blood TSH and free L-thyroxine (fT) levels. In this descriptive study, a questionnaire with a face-to-face interview was administered before birth, and cord blood samples were taken immediately after delivery. The mean levels of BPA, BPF, TSH, and fT were measured as 10.69 ± 2.39 ng/ml, 3.80 ± 0.58 ng/ml; 2.36 ± 0.23 µIU/ml, and 14.18 ± 0.53 pg/ml, respectively, in a total of 104 cord blood samples. All BPS levels remained below the detection limit. Linear regression analysis revealed a positive association between birth weight and cord blood BPA concentration (β = 0.26;  = 0.02). Further research on maternal exposure during the fetal and neonatal period is critical for public health.

摘要

环境内分泌干扰化学物质是公共卫生关注的一个问题,特别是胎儿暴露于双酚衍生物中。本研究旨在通过测量脐带血中的双酚衍生物(BPA、BPF 和 BPS)水平,并调查其与日常生活中使用的塑料材料之间的关系,以及脐带血 TSH 和游离 L-甲状腺素(fT)水平,来评估胎儿暴露于双酚衍生物的情况。在这项描述性研究中,在出生前通过问卷调查和面对面访谈进行了评估,并在分娩后立即采集脐带血样本。在总共 104 份脐带血样本中,BPA、BPF、TSH 和 fT 的平均水平分别为 10.69±2.39ng/ml、3.80±0.58ng/ml、2.36±0.23µIU/ml 和 14.18±0.53pg/ml。所有 BPS 水平均低于检测限。线性回归分析显示,出生体重与脐带血 BPA 浓度呈正相关(β=0.26;P=0.02)。进一步研究胎儿和新生儿期的母体暴露情况对公共卫生至关重要。

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