JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Front Endocrinol (Lausanne). 2024 Jul 1;15:1420540. doi: 10.3389/fendo.2024.1420540. eCollection 2024.
Evidence from animal experiments and epidemiological studies has reported controversial results about the effects of prenatal bisphenols (BPs) exposure on childhood thyroid function. This study aims to explore the associations of prenatal exposure to BPs with thyroid-related hormones (THs) in newborns and early childhood, with a particular focus on the sex-dependent and exposure level effects.
Correlated studies were systematically searched from PubMed, Web of Science, Medline, Cochrane, and Embase until February 21, 2024. The exposures assessed include bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS), bisphenol AF (BPAF), and tetrachlorobisphenol A (TCBPA). THs measured were thyroid stimulating hormone (TSH), total tri-iodothyronine (TT3), total thyroxine (TT4), free tri-iothyronine (FT3), and free thyroxine (FT4). Effect estimates were quantified using coefficients from multivariable regression models. Statistical analyses were completed using Stata 16.0. The methodological quality of the included studies was evaluated using the Newcastle-Ottawa Scale (NOS).
Eleven cohort studies comprising 5,363 children were included in our meta-analysis. Prenatal bisphenol concentrations were statistically significant related to alterations in thyroid hormones in children, exclusively in female offspring, including reduced TSH (β = -0.020, 95% CI: -0.036, -0.005) and increased TT3 levels (β = 0.011, 95% CI: 0.001, 0.021), and exposure to high concentration of bisphenols (>1.5 ug/g creatinine) significantly reduced FT3 levels in children (β = -0.011, 95% CI: -0.020, -0.003).
Prenatal bisphenol exposure is linked to alterations in thyroid hormone levels in girls, necessitating enhanced measures to control bisphenol exposure levels during pregnancy for child health protection.
https://inplasy.com, identifier INPLASY202450129.
动物实验和流行病学研究的证据报告了产前双酚（BPs）暴露对儿童甲状腺功能的影响存在争议的结果。本研究旨在探讨新生儿和幼儿期产前暴露于 BPs 与甲状腺相关激素（THs）的关联，特别关注性别依赖性和暴露水平的影响。
系统地从 PubMed、Web of Science、Medline、Cochrane 和 Embase 搜索相关研究，截至 2024 年 2 月 21 日。评估的暴露包括双酚 A（BPA）、双酚 F（BPF）、双酚 S（BPS）、双酚 AF（BPAF）和四氯双酚 A（TCBPA）。测量的 THs 包括促甲状腺激素（TSH）、总三碘甲状腺原氨酸（TT3）、总甲状腺素（TT4）、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）。使用多变量回归模型的系数来量化效应估计值。使用 Stata 16.0 完成统计分析。使用纽卡斯尔-渥太华量表（NOS）评估纳入研究的方法学质量。
我们的荟萃分析包括 11 项队列研究，共 5363 名儿童。产前双酚浓度与儿童甲状腺激素的变化有统计学意义，仅在女性后代中，包括 TSH 降低（β=-0.020，95%CI：-0.036，-0.005）和 TT3 水平升高（β=0.011，95%CI：0.001，0.021），并且暴露于高浓度双酚（>1.5μg/g 肌酐）显著降低儿童的 FT3 水平（β=-0.011，95%CI：-0.020，-0.003）。
产前双酚暴露与女孩甲状腺激素水平的变化有关，需要在妊娠期间采取措施控制双酚暴露水平，以保护儿童健康。
https://inplasy.com，标识符 INPLASY202450129。
