Berridge M V, O'Kech N, McNeilage L J, Heslop B F, Moore R
Transplantation. 1979 Jun;27(6):410-3.
A new rat mutant (nznu) is described which shows characteristics similar to those of the nude mouse. The mutant is an autosomal recessive. Homozygotes are essentially hairless (except for stunted vibriassae) and show deficient thymus gland development. Under conventional breeding conditions the mutants are difficult to raise and few survive weaning. The absence of functional thymus-derived lymphocytes in the nude rat is implied by (1) acceptance of histoincompatible skin grafts, (2) lack of response to the T cell mitogens phytohaemagglutinin and concanvalin A, and (3) absence of cells sensitive to alloantiserum directed against rat thymus-derived lymphocytes. Although total blood leukocytes from the nude rat were within the normal range, differential counting of leukocytes showed a 4-fold elevation of neutrophils and a 2.5-fold reduction of lymphocytes, compared with normal rats. Phenotypically normal heterozygotes gave values intermediate between nude and normal rats.
描述了一种新的大鼠突变体（nznu），其表现出与裸鼠相似的特征。该突变体为常染色体隐性遗传。纯合子基本无毛（除了发育不良的触须），且胸腺发育不全。在常规饲养条件下，突变体难以饲养，很少有能存活到断奶的。裸鼠缺乏功能性胸腺来源的淋巴细胞可由以下几点推断：（1）接受组织不相容的皮肤移植；（2）对T细胞有丝分裂原植物血凝素和刀豆球蛋白A无反应；（3）不存在对针对大鼠胸腺来源淋巴细胞的同种抗血清敏感的细胞。尽管裸鼠的全血白细胞在正常范围内，但与正常大鼠相比，白细胞分类计数显示中性粒细胞升高了4倍，淋巴细胞减少了2.5倍。表型正常的杂合子给出的值介于裸鼠和正常大鼠之间。
