Hurtado Maria D, Tama Elif, D'Andre Stacey, Shufelt Chrisandra L
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Jacksonville, FL, USA; Precision Medicine for Obesity Program, Mayo Clinic, Rochester, MN, USA.
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Jacksonville, FL, USA; Precision Medicine for Obesity Program, Mayo Clinic, Rochester, MN, USA.
Crit Rev Oncol Hematol. 2024 Jan;193:104213. doi: 10.1016/j.critrevonc.2023.104213. Epub 2023 Nov 24.
Breast cancer (BC) is the most common cancer in women. While the combination of improved screening, earlier detection, and advances in therapeutics has resulted in lower BC mortality, BC survivors are now increasingly dying of cardiovascular disease. Cardiovascular disease in the leading cause of non-cancer related mortality among BC survivors. This situation underscores the critical need to research the role of modifiable cardiometabolic risk factors, such as excess adiposity, that will affect BC remission, long-term survivorship, and overall health and quality of life.
First, this review summarizes the evidence on the connection between adipose tissue and BC. Then we review the data on weight trends after BC diagnosis with a focus on the effect of weight gain on BC recurrence and BC- and non-BC-related death. Finally, we provide a guide for weight management in BC survivors, considering the available data on the effect of weight loss interventions on BC.
乳腺癌是女性中最常见的癌症。尽管筛查改善、早期检测及治疗进展相结合已降低了乳腺癌死亡率，但乳腺癌幸存者如今越来越多地死于心血管疾病。心血管疾病是乳腺癌幸存者中非癌症相关死亡的主要原因。这种情况凸显了研究可改变的心脏代谢危险因素（如肥胖过多）作用的迫切需求，这些因素会影响乳腺癌缓解、长期生存以及整体健康和生活质量。
首先，本综述总结了关于脂肪组织与乳腺癌之间联系的证据。然后我们回顾乳腺癌诊断后体重趋势的数据，重点关注体重增加对乳腺癌复发以及乳腺癌相关和非乳腺癌相关死亡的影响。最后，考虑到关于体重减轻干预对乳腺癌影响的现有数据，我们为乳腺癌幸存者的体重管理提供指导。
