Division of Spine, Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China; Key Laboratory of Spine and Spinal cord Injury Repair and Regeneration (Tongji University), Ministry of Education, Shanghai 200072, China; Medical School, Tongji University, Shanghai 200433, China.
Division of Spine, Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China; Key Laboratory of Spine and Spinal cord Injury Repair and Regeneration (Tongji University), Ministry of Education, Shanghai 200072, China; School of Stomatology, Tongji University, Shanghai 200072, China.
Life Sci. 2024 Jan 1;336:122282. doi: 10.1016/j.lfs.2023.122282. Epub 2023 Nov 24.
As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its specific receptor Tropomyosin-related kinase receptor B (TrkB). The BDNF/TrkB signaling pathway is crucial for neuronal survival, structural changes, and plasticity. BDNF acts as an axonal growth and extension factor, a pro-survival factor, and a synaptic modulator in the CNS. BDNF also plays an important role in the maintenance and plasticity of neuronal circuits. Several studies have demonstrated the importance of BDNF in the treatment and recovery of neurodegenerative and neurotraumatic disorders. By undertaking in-depth study on the mechanism of BDNF/TrkB function, important novel therapeutic strategies for treating neuropsychiatric disorders have been discovered. In this review, we discuss the expression patterns and mechanisms of the TrkB/BDNF signaling pathway in CNS damage and introduce several intriguing small molecule TrkB receptor agonists produced over the previous several decades.
作为中枢神经系统 (CNS) 中最普遍的神经营养因子之一，脑源性神经营养因子 (BDNF) 通过与其特定受体 Tropomyosin-related kinase receptor B (TrkB) 结合，在 CNS 损伤中发挥重要作用。BDNF/TrkB 信号通路对于神经元的存活、结构变化和可塑性至关重要。BDNF 在 CNS 中充当轴突生长和延伸因子、生存促进因子和突触调节剂。BDNF 还在神经元回路的维持和可塑性中发挥重要作用。几项研究表明 BDNF 在治疗神经退行性和神经创伤性疾病中的重要性。通过深入研究 BDNF/TrkB 功能的机制，发现了治疗神经精神疾病的重要新的治疗策略。在这篇综述中，我们讨论了 TrkB/BDNF 信号通路在 CNS 损伤中的表达模式和机制，并介绍了过去几十年中产生的几种有趣的小分子 TrkB 受体激动剂。
