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[因使用合成代谢类固醇进行健美运动继发的塌陷性肾小球病:病例系列]

[Collapsing Glomerulopathy Secondary to Anabolic Steroids for Bodybuilding: A Case Series].

作者信息

Passaro Roberta, D'Angiò Pierluigi, Laurino Simona, Gigliotti Giuseppe, Massa Antonio, Mancini Antonio, Gonnella Annalisa, Giammarino Anna, Borriello Gianmarco

机构信息

Dipartimento di Sanità Pubblica, Università degli Studi di Napoli "Federico II", Napoli, Italia.

UOC Nefrologia e Dialisi, PO Maria SS. Addolorata, Eboli, Italia.

出版信息

G Ital Nefrol. 2023 Oct 26;40(5):2023-vol5.

Abstract

The abuse of anabolic androgenic steroids (AAS) for competitive (and non-competitive) purposes for bodybuilding practice is increasingly common. The consequences of these substances on the various organs are only partially known. Cases of FSGS following the use of AAS have been reported in the literature, even with evolution to ESKD. We describe three cases of bodybuilding athletes who presented alterations in renal function indices after taking AAS for a long time. Three renal biopsies were performed with histological diagnosis of FSGS collapsing variant. We examine the lesions observed on histological examination. Two athletes had rapid progression of renal disease requiring replacement therapy. The third one continues conservative treatment for chronic renal failure. We discuss the risks related to the intake of doping substances and how bodybuilders are exposed to different causes of kidney damage: anabolic steroids, supplements, and a high-protein diet.

摘要

出于健美锻炼的竞争(及非竞争)目的而滥用合成代谢雄激素类固醇(AAS)的情况日益普遍。这些物质对各个器官的影响仅部分为人所知。文献中已有使用AAS后发生局灶节段性肾小球硬化(FSGS)的病例报道,甚至有进展至终末期肾病(ESKD)的情况。我们描述了三例健美运动员在长期服用AAS后出现肾功能指标改变的病例。进行了三次肾活检,组织学诊断为塌陷型FSGS。我们检查了组织学检查中观察到的病变。两名运动员肾病进展迅速,需要替代治疗。第三名运动员继续接受慢性肾衰竭的保守治疗。我们讨论了与摄入兴奋剂相关的风险,以及健美运动员如何暴露于不同的肾损伤原因:合成代谢类固醇、补充剂和高蛋白饮食。

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