Igarashi T, Tomihari N, Ohmori S, Ueno K, Kitagawa H, Satoh T
Biochem Int. 1986 Oct;13(4):641-8.
The glutathione S-transferases (GSTs) of hepatic cytosol of rats, mice, guinea pigs, rabbits and hamsters were simultaneously investigated with respect to substrate specificity, subunit composition and elution profile of GSTs. The activity towards 1-chloro-2,4-dinitrobenzene was the highest in hamsters, followed by rabbits, guinea pigs, mice and rats. On the analysis of SDS-PAGE, Ya subunit band of GST was detected in only rats, not others. There was also seen a marked species difference in elution profile of GST activity on S-sepharose column. The elution patterns from rats, mice and rabbits were quite different from hamsters and guinea pigs.
同时研究了大鼠、小鼠、豚鼠、兔子和仓鼠肝细胞溶质中的谷胱甘肽S-转移酶（GSTs），涉及GSTs的底物特异性、亚基组成和洗脱图谱。仓鼠对1-氯-2,4-二硝基苯的活性最高，其次是兔子、豚鼠、小鼠和大鼠。在SDS-PAGE分析中，仅在大鼠中检测到GST的Ya亚基带，其他动物未检测到。在S-琼脂糖柱上GST活性的洗脱图谱也存在明显的物种差异。大鼠、小鼠和兔子的洗脱模式与仓鼠和豚鼠有很大不同。
