School of Chemical Engineering and Technology, Tianjin University, Tianjin Key Laboratory of Membrane Science and Desalination Technology, State Key Laboratory of Chemical Engineering (Tianjin University), Tianjin, 300072, P. R. China.
Tianjin Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin, 300170, P. R. China.
Adv Healthc Mater. 2024 Feb;13(5):e2302708. doi: 10.1002/adhm.202302708. Epub 2023 Dec 3.
The oxygenation membrane, a core material of extracorporeal membrane oxygenation (ECMO), is facing challenges in balancing anti-plasma leakage, gas exchange efficiency, and hemocompatibility. Here, inspired by the asymmetric structural features of alveolus pulmonalis, a novel triple-functional membrane for blood oxygenation with a Janus architecture is proposed, which is composed of a hydrophobic polydimethylsiloxane (PDMS) layer to prevent plasma leakage, an ultrathin polyamide layer to enhance gas exchange efficiency with a CO :O permeance ratio of ≈10.7, and a hydrophilic polyzwitterionic layer to improve the hemocompatibility. During the simulated ECMO process, the Janus oxygenation membrane exhibits excellent performance in terms of thrombus formation and plasma leakage prevention, as well as adequate O transfer rate (17.8 mL min m ) and CO transfer rate (70.1 mL min m ), in comparison to the reported oxygenation membranes. This work presents novel concepts for the advancement of oxygenation membranes and demonstrates the application potential of the asymmetric triple-functional Janus oxygenation membrane in ECMO.
氧合膜是体外膜肺氧合（ECMO）的核心材料，在平衡抗血浆渗漏、气体交换效率和血液相容性方面面临挑战。在这里，受肺泡不对称结构特征的启发，提出了一种具有 Janus 结构的新型三重功能血液氧合膜，它由疏水性聚二甲基硅氧烷（PDMS）层组成，以防止血浆渗漏，超薄聚酰胺层可提高气体交换效率，CO：O 透过率比约为 10.7，亲水性聚两性离子层可提高血液相容性。在模拟 ECMO 过程中，与报道的氧合膜相比，Janus 氧合膜在血栓形成和防止血浆渗漏方面表现出优异的性能，并且具有足够的 O 传递率（17.8mL min m ）和 CO 传递率（70.1mL min m ）。这项工作为氧合膜的发展提出了新的概念，并展示了不对称三重功能 Janus 氧合膜在 ECMO 中的应用潜力。
