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[男性不育、环境与生活方式]

[Male infertility, environment and lifestyle].

作者信息

Methorst C, Perrin J, Faix A, Huyghe E

机构信息

Service de médecine de la reproduction, hôpital des 4 villes, Saint-Cloud, France.

Biologie et médecine de la reproduction et du développement, CHU de Marseille, UMR 7263 IMBE, Marseille, France.

出版信息

Prog Urol. 2023 Nov;33(13):613-623. doi: 10.1016/j.purol.2023.09.014.

Abstract

BACKGROUND

Since the 1970s, there has been a quantitative and qualitative decline in sperm parameters. The main hypothesis to explain such a rapid evolution is the involvement of environmental and behavioral phenomena.

METHODS

A bibliographic search limited to English and French literature in men published before 7/2023 was carried out on the links between fertility and pollution, xenobiotics, tobacco, narcotics, cannabis, alcohol, weight, sport, sedentary lifestyle, sleep and anabolics.

RESULTS

Profound changes in lifestyle have occurred over the past 50 years: reduced sleep time, sedentary lifestyle, dietary changes, tobacco consumption, use of narcotics and anabolics. These changes have a proven impact on spermogram parameters, and should be corrected in an effort to optimize reproductive health. Other environmental parameters: pollution, exposure to heavy metals, exposure to xenobiotics, phthalates and pesticides… will be more difficult to exclude from patients' daily lives, but deserve to be taken more into account.

CONCLUSION

This review should help the urologist to assess and counsel patients in order to improve their reproductive health. These factors should be routinely investigated in infertile men.

摘要

背景

自20世纪70年代以来,精子参数出现了数量和质量上的下降。解释这种快速演变的主要假说是环境和行为现象的影响。

方法

对截至2023年7月前发表的关于男性生育与污染、外源性物质、烟草、麻醉品、大麻、酒精、体重、运动、久坐生活方式、睡眠和合成代谢类固醇之间联系的英文和法文文献进行了文献检索。

结果

在过去50年中,生活方式发生了深刻变化:睡眠时间减少、久坐生活方式、饮食改变、吸烟、使用麻醉品和合成代谢类固醇。这些变化已被证明对精液分析参数有影响,应加以纠正以优化生殖健康。其他环境参数:污染、接触重金属、接触外源性物质、邻苯二甲酸盐和杀虫剂……将更难从患者的日常生活中排除,但值得更多关注。

结论

本综述应有助于泌尿科医生评估和咨询患者,以改善他们的生殖健康。这些因素应在不育男性中进行常规调查。

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