Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
J Ethnopharmacol. 2024 Mar 1;321:117492. doi: 10.1016/j.jep.2023.117492. Epub 2023 Nov 25.
Kai-Xin-San (KXS, or Happy Feeling Powder), a typical Chinese herbal prescription, is frequently used for treating depression by the multi-level and multi-target mechanism.
To systematically investigate the efficacy and safety of KXS on depression in preclinic trials.
We independently searched for preclinical animal studies of KXS on depression from inception to June 28, 2022, using electronic databases, e.g., PUBMED. The measurements were performed to assess the outcomes of behavioral tests.
This systematic review and meta-analysis included twenty-four studies and 608 animals. A remarkable effect of KXS in depression behavioral tests, including sucrose consumption test (SMD: 2.36, 95% CI: (1.81, 2.90); Z = 8.49, P < 0.00001)., forced swimming test (MD = -60.52, 95% CI: (-89.04, -31.99); Z = 4.16, P < 0.0001), rearing times (MD=4.48, 95% CI: (3.39, 5.57); Z = 8.05, P < 0.00001) and crossing times (MD = -33.7, 95% CI: (25.74, 41.67); Z = 8.29, P < 0.00001) in the open field test, showing KXS's excellent efficiency in improving depressive-like symptoms of animals.
Our meta-analysis showed KXS remarkably relieved animals' depressive-like symptoms, providing evidence that KXS can be a promising drug candidate for depression treatment.
草药开心散治疗抑郁症的临床前疗效和安全性的系统评价和荟萃分析
系统评价和荟萃分析草药开心散（KXS）治疗抑郁症的临床前疗效和安全性。
我们独立检索了从建库到 2022 年 6 月 28 日期间电子数据库（如 PUBMED）中关于 KXS 治疗抑郁症的临床前动物研究，使用行为测试来评估结局测量。
本系统评价和荟萃分析共纳入 24 项研究，涉及 608 只动物。KXS 在抑郁行为测试中具有显著疗效，包括蔗糖消耗试验（SMD：2.36，95%CI：1.81，2.90；Z=8.49，P<0.00001）、强迫游泳试验（MD=-60.52，95%CI：-89.04，-31.99；Z=4.16，P<0.0001）、直立次数（MD=4.48，95%CI：3.39，5.57；Z=8.05，P<0.00001）和穿越次数（MD=-33.7，95%CI：25.74，41.67；Z=8.29，P<0.00001），表明 KXS 能有效改善动物的抑郁样症状。
我们的荟萃分析表明 KXS 能显著缓解动物的抑郁样症状，为 KXS 可能成为治疗抑郁症的有前途的候选药物提供了证据。
