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中药方剂柴胡疏肝散对抑郁症动物模型的疗效及潜在机制：系统评价与Meta分析

Efficacy and Potential Mechanism of Chinese Herbal Formula Chaihu Shugan Powder on Animal Models of Depression: A Systematic Review and Meta-Analysis.

作者信息

Wu Lulu, Deng Yi, Yu Liyuan, Peng Weihang, Li Ya, Feng Yuchao, Chen Li, Huang Peiying, Chen Bojun

机构信息

The Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

Clinical Research Team of Prevention and Treatment of Cardiac Emergencies With Traditional Chinese Medicine, Guangdong Provincial Academy of Traditional Chinese Medicine, Guangzhou, China.

出版信息

CNS Neurosci Ther. 2025 Apr;31(4):e70375. doi: 10.1111/cns.70375.

DOI:10.1111/cns.70375
PMID:40202374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11980094/
Abstract

BACKGROUND: Chaihu Shugan powder (CSP) is used in the clinical treatment of depression. However, its clinical mechanisms remain elusive. While acknowledging the extensive animal research, there is a need for systematic meta-analysis for comprehensive understanding. This study aims to evaluate the efficacy of CSP and its mechanisms in animal models of depression. METHODS: Animal studies on the antidepressant effects of CSP were reviewed in databases including PubMed, Web of Science, Cochrane Library, Embase database, CNKI, VIP, WangFang database, and CBM published before March 12, 2024. The R Studio software was used for statistical analyses. RESULTS: The present systematic review included 23 studies. The results revealed that CSP has a significant effect on behavior forced swimming test (FST) (SMD = -1.44, 95% CI: -1.87, -1.00); sucrose preference test (SPT) (SMD = 3.63, 95% CI: 1.87, 5.39), rearing numbers of open field test (OFT) (SMD = 1.46, 95% CI: 0.95, 1.96); crossing numbers of OFT (SMD = 2.15, 95% CI: 1.30, 3.01); and body weight (SMD = 2.16, 95% CI: 1.13, 3.18). CONCLUSION: In summary, this study revealed that CSP could treat depression symptoms in animals, which is associated with its anti-inflammatory effects, regulation of the HPA axis, neurotrophic factors, and glucose metabolism.

摘要

背景：柴胡疏肝散（CSP）用于抑郁症的临床治疗。然而，其临床机制仍不清楚。尽管已有大量动物研究，但仍需要进行系统的荟萃分析以全面了解。本研究旨在评估CSP在抑郁症动物模型中的疗效及其机制。 方法：检索了截至2024年3月12日在PubMed、Web of Science、Cochrane图书馆、Embase数据库、中国知网（CNKI）、维普资讯（VIP）、万方数据库和中国生物医学文献数据库（CBM）上发表的关于CSP抗抑郁作用的动物研究。使用R Studio软件进行统计分析。 结果：本系统评价纳入了23项研究。结果显示，CSP对行为绝望实验（FST）（标准化均数差[SMD]=-1.44，95%置信区间[CI]：-1.87，-1.00）、蔗糖偏好实验（SPT）（SMD=3.63，95%CI：1.87，5.39）、旷场实验（OFT）直立次数（SMD=1.46，95%CI：0.95，1.96）、OFT穿越次数（SMD=2.15，95%CI：1.30，3.01）和体重（SMD=2.16，95%CI：1.13，3.18）有显著影响。 结论：总之，本研究表明CSP可治疗动物的抑郁症状，这与其抗炎作用、对下丘脑-垂体-肾上腺（HPA）轴的调节、神经营养因子和糖代谢有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00bf/11980094/dd614473944b/CNS-31-e70375-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00bf/11980094/811275c70d54/CNS-31-e70375-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00bf/11980094/bed7e13f7bc9/CNS-31-e70375-g010.jpg
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[2]
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[3]
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[4]
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Int J Mol Sci. 2022-12-29

[5]
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[6]
Novel and emerging treatments for major depression.

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[7]
SIRT1/FOXO1 Axis-Mediated Hippocampal Angiogenesis is Involved in the Antidepressant Effect of Chaihu Shugan San.

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[8]
Major Depression and Its Recurrences: Life Course Matters.

Annu Rev Clin Psychol. 2022-5-9

[9]
Time for united action on depression: a Lancet-World Psychiatric Association Commission.

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[10]
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