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细胞死亡分类:基于分子机制的新见解。

Cell death classification: A new insight based on molecular mechanisms.

机构信息

Department of Medical Basic Sciences, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Exp Cell Res. 2023 Dec 15;433(2):113860. doi: 10.1016/j.yexcr.2023.113860. Epub 2023 Nov 26.

Abstract

Cells tend to disintegrate themselves or are forced to undergo such destructive processes in critical circumstances. This complex cellular function necessitates various mechanisms and molecular pathways in order to be executed. The very nature of cell death is essentially important and vital for maintaining homeostasis, thus any type of disturbing occurrence might lead to different sorts of diseases and dysfunctions. Cell death has various modalities and yet, every now and then, a new type of this elegant procedure gets to be discovered. The diversity of cell death compels the need for a universal organizing system in order to facilitate further studies, therapeutic strategies and the invention of new methods of research. Considering all that, we attempted to review most of the known cell death mechanisms and sort them all into one arranging system that operates under a simple but subtle decision-making (If \ Else) order as a sorting algorithm, in which it decides to place and sort an input data (a type of cell death) into its proper set, then a subset and finally a group of cell death. By proposing this algorithm, the authors hope it may solve the problems regarding newer and/or undiscovered types of cell death and facilitate research and therapeutic applications of cell death.

摘要

在危急情况下,细胞往往会自行解体或被迫经历这种破坏性过程。这种复杂的细胞功能需要各种机制和分子途径来执行。细胞死亡的本质对于维持体内平衡至关重要,因此任何类型的干扰事件都可能导致不同类型的疾病和功能障碍。细胞死亡有多种形式,但不时地,这种优雅过程的一种新类型被发现。细胞死亡的多样性迫使我们需要一个通用的组织系统,以便于进一步的研究、治疗策略和新的研究方法的发明。考虑到所有这些,我们试图回顾大多数已知的细胞死亡机制,并将它们全部整理到一个排列系统中,该系统在一个简单但微妙的决策(如果\否则)顺序下运行,作为一种排序算法,它决定将输入数据(一种细胞死亡类型)放置并排序到其适当的集合中,然后是子集,最后是一组细胞死亡。通过提出这个算法,作者希望它可以解决新的和/或未发现的细胞死亡类型的问题,并促进细胞死亡的研究和治疗应用。

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