Departamento de Bioquímica & Instituto de Investigaciones Biomédicas "Alberto Sols", The Autonomous University of Madrid-Consejo Superior de Investigaciones Científicas, Spain.
LAGENBIO, Departamento de Anatomía, Embriología y Genética Animal, Facultad de Veterinaria, Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza, Spain.
FEBS Open Bio. 2024 Feb;14(2):276-289. doi: 10.1002/2211-5463.13742. Epub 2023 Dec 19.
Mitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1-associated protein, PSAP. MTCH2 is a receptor for tBid and is related to lipid metabolism. Both proteins have been recently described as protein insertases of the outer mitochondrial membrane. We have depleted Mtch in Drosophila and show here that mutant flies are unable to complete development, showing an excess of apoptosis during pupation; this observation was confirmed by RNAi in Schneider cells. These findings are contrary to what has been described in humans. We discuss the implications in view of recent reports concerning the function of these proteins.
线粒体载体同源物 1（MTCH1）和 2（MTCH2）是线粒体转运体家族 SLC25 的孤儿成员。人类 MTCH1 也被称为早老素 1 相关蛋白 PSAP。MTCH2 是 tBid 的受体，与脂质代谢有关。这两种蛋白质最近都被描述为外线粒体膜的蛋白插入酶。我们已经在果蝇中耗尽了 Mtch，并在此表明突变果蝇无法完成发育，在蛹化过程中出现过多的细胞凋亡；这一观察结果在 Schneider 细胞中的 RNAi 实验中得到了证实。这些发现与在人类中描述的情况相反。鉴于最近有关这些蛋白质功能的报告，我们讨论了其意义。
