Department of paediatrics，Linyi central hospital of Shandong province，Linyi，276400，Shandong，China.
Cell Mol Biol (Noisy-le-grand). 2020 Sep 30;66(6):41-45.
Mycoplasma is a gram-negative with thin wall bacterium that in humans, Mycoplasma pneumoniae causes pneumonia. This experiment was designed to explore the changes of myocardial enzymes in the mycoplasma pneumoniae pneumonia (MPP) child patients, and analyze the clinical value of these changes, in combination with the relevant indicators, symptoms and signs, in the evaluation of the pneumonia mycoplasma infection. For this aim, a total of 120 child patients with MPP in the acute phase,120 child patients with MPP in the recovery phase and 120 healthy children were simultaneously enrolled into this study to detect the levels of aspartate aminotransferase (AST), creatine kinase (CK), Creatine Kinase Isoenzyme (CK-MB) and lactic dehydrogenase (LDH) in blood. Results showed that MPP patients in the acute phase had higher levels of LDH, CK, CK-MB, AST, PCt, CRP, MPV, PDW, PCt, percentage of neutrophils, WBC count in the peripheral blood and ESR than those of the patients in the recovery patients and healthy children, while the level of PLT was lower (all P<0.05). In the acute phase, the level of CK-MB correlated to the fever, fever duration, extrapulmonary organ damage (except for the myocardial damage) and the antibody titer of MP (all P<0.05). It was concluded that in the acute phase of MMP, the level of CK-MB could not only reflect the myocardial damage readily but also the infection of MP as well as the resultant inflammation and disease progression, which could effectively guide the diagnosis and treatment of MPP.
支原体是一种革兰氏阴性、壁薄的细菌，在人类中，肺炎支原体可引起肺炎。本实验旨在探讨肺炎支原体肺炎（MPP）患儿心肌酶谱的变化，并结合相关指标、症状和体征，分析其在评价肺炎支原体感染中的临床价值。为此，本研究同时纳入 120 例急性 MPP 患儿、120 例恢复期 MPP 患儿和 120 例健康儿童，检测血液中天冬氨酸氨基转移酶（AST）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）和乳酸脱氢酶（LDH）水平。结果显示，急性 MPP 患儿的 LDH、CK、CK-MB、AST、PCt、CRP、MPV、PDW、PCt、中性粒细胞百分比、外周血白细胞计数和 ESR 均高于恢复期患儿和健康儿童，PLT 水平较低（均 P<0.05）。在急性期，CK-MB 水平与发热、发热持续时间、肺外器官损害（心肌损害除外）和 MP 抗体滴度相关（均 P<0.05）。综上所述，在 MMP 的急性期，CK-MB 水平不仅能迅速反映心肌损伤，还能反映 MP 感染以及由此引起的炎症和疾病进展，可有效指导 MPP 的诊断和治疗。
