Population Health Science Institute, Newcastle University, Newcastle, UK.
Birth Defects Res. 2024 Jan;116(1):e2275. doi: 10.1002/bdr2.2275. Epub 2023 Nov 28.
Research on cognitive and school functioning domains of health-related quality of life (HRQOL) for children and adolescents with congenital heart disease (CHD) presents inconsistencies.
To summarize and synthesize data on school and cognitive function domains of HRQOL for children and young people (CYP) with CHD.
Five electronic databases MEDLINE, Scopus, PsycINFO, EMBASE, ERI, and citations were systematically searched. We included original-research articles reporting the cognitive and school function domains of HRQOL for children and young people with CHD (child and parent reports included). Both fixed and random-effects meta-analyses were performed to estimate pooled mean test scores for cognitive and school function. A total of 34 studies met our inclusion criteria and were synthesized narratively, 17 studies were included in formal meta-analyses.
Self-reported cognitive function was lower for children and young people with CHD than healthy controls (SMD -0.28 (-0.42, -0.15)). Parental reports demonstrated similar results to self-reports (SMD -0.54 (-0.91, -0.18)). School function was lower in children and young people with CHD compared with healthy controls in self-reported (SMD -0.30 (-0.48, -0.13)) and parent reported HRQOL (SMD -0.49 (0.64, -0.36)). Self-reported school function domain scores were lower for young (<8 years) (SMD -0.65 (-1.32, 0.03)) and older children (8-18 years) (SMD -0.25 (-0.47, -0.03)) with CHD than their peers. Similarly, parents reported lower school function domain scores for young (<8 years) (SMD -0.68 (-1.29, -0.07)) and older (8-18 years) (SMD -0.46 (-068, -0.25)) children with CHD than typically developing peers.
Children born with CHD may experience lower cognitive and school function HRQOL scores than healthy controls (self and proxy-report). This is consistent with a subgroup meta-analysis of young (<8 years) and older (8 years old or more) children with CHD reporting lower school function scores compared to controls.
针对先天性心脏病（CHD）儿童和青少年健康相关生活质量（HRQOL）的认知和学校功能领域的研究结果不一致。
总结和综合评估 CHD 儿童和青少年 HRQOL 的学校和认知功能领域的数据。
系统检索了 MEDLINE、Scopus、PsycINFO、EMBASE、ERI 等五个电子数据库和引文。我们纳入了报告 CHD 儿童和青少年 HRQOL 认知和学校功能领域的原始研究文章（包括儿童和家长报告）。进行固定效应和随机效应荟萃分析以估计认知和学校功能的汇总平均测试分数。共有 34 项研究符合纳入标准，并进行了叙述性综合，17 项研究纳入了正式的荟萃分析。
与健康对照组相比，CHD 儿童和青少年的自我报告认知功能较低（SMD -0.28（-0.42，-0.15））。父母报告的结果与自我报告相似（SMD -0.54（-0.91，-0.18））。与健康对照组相比，CHD 儿童和青少年的自我报告 HRQOL（SMD -0.30（-0.48，-0.13））和家长报告 HRQOL（SMD -0.49（0.64，-0.36））的学校功能较低。与同龄人相比，患有 CHD 的年轻（<8 岁）（SMD -0.65（-1.32，0.03））和年龄较大的儿童（8-18 岁）（SMD -0.25（-0.47，-0.03））自我报告的学校功能域得分较低。同样，父母报告患有 CHD 的年轻（<8 岁）（SMD -0.68（-1.29，-0.07））和年龄较大（8-18 岁）（SMD -0.46（-0.68，-0.25））儿童的学校功能域得分低于典型发展的同龄人。
与健康对照组相比，患有 CHD 的儿童可能具有较低的认知和学校功能 HRQOL 评分（自我报告和代理报告）。这与年轻（<8 岁）和年龄较大（8 岁或以上）CHD 儿童报告的学校功能评分低于对照组的亚组荟萃分析一致。
