Translational Research Center for TBI and Stress Disorders and Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
J Int Neuropsychol Soc. 2024 May;30(4):410-419. doi: 10.1017/S1355617723000711. Epub 2023 Nov 28.
Performance validity (PVTs) and symptom validity tests (SVTs) are necessary components of neuropsychological testing to identify suboptimal performances and response bias that may impact diagnosis and treatment. The current study examined the clinical and functional characteristics of veterans who failed PVTs and the relationship between PVT and SVT failures.
Five hundred and sixteen post-9/11 veterans participated in clinical interviews, neuropsychological testing, and several validity measures.
Veterans who failed 2+ PVTs performed significantly worse than veterans who failed one PVT in verbal memory (Cohen's .60-.69), processing speed (Cohen's .68), working memory (Cohen's = .98), and visual memory (Cohen's .88-1.10). Individuals with 2+ PVT failures had greater posttraumatic stress (PTS; = 0.16; = .0002), and worse self-reported depression ( = 0.17; = .0001), anxiety ( = 0.15; = .0007), sleep ( = 0.10; = .0233), and functional outcomes ( = 0.15; = .0009) compared to veterans who passed PVTs. 7.8% veterans failed the SVT (Validity-10; ≥19 cutoff); Multiple PVT failures were significantly associated with Validity-10 failure at the ≥19 and ≥23 cutoffs ('s < .0012). The Validity-10 had moderate correspondence in predicting 2+ PVTs failures ( = 0.83; = 0.76, 0.91).
PVT failures are associated with psychiatric factors, but not traumatic brain injury (TBI). PVT failures predict SVT failure and vice versa. Standard care should include SVTs and PVTs in all clinical assessments, not just neuropsychological assessments, particularly in clinically complex populations.
在神经心理测试中,绩效有效性(PVTs)和症状有效性测试(SVTs)是必要的组成部分,以识别可能影响诊断和治疗的次优表现和反应偏差。本研究检查了 PVT 失败的退伍军人的临床和功能特征,以及 PVT 和 SVT 失败之间的关系。
516 名 9/11 后退伍军人参加了临床访谈、神经心理测试和几项有效性测试。
与仅失败一次 PVT 的退伍军人相比,失败 2 次及以上 PVT 的退伍军人在言语记忆(Cohen's.60-.69)、加工速度(Cohen's.68)、工作记忆(Cohen's.98)和视觉记忆(Cohen's.88-1.10)方面表现明显更差。PVT 失败 2 次及以上的个体创伤后应激(PTS; = 0.16; =.0002)和自我报告的抑郁( = 0.17; =.0001)、焦虑( = 0.15; =.0007)、睡眠( = 0.10; =.0233)和功能结果( = 0.15; =.0009)更差,与通过 PVT 的退伍军人相比。7.8%的退伍军人(Validity-10;≥19 分检出率)失败了 SVT;多个 PVT 失败与 Validity-10 在≥19 和≥23 截断值处的失败显著相关('s <.0012)。Validity-10 对 2 次及以上 PVT 失败的预测具有中等一致性( = 0.83; = 0.76、0.91)。
PVT 失败与精神因素有关,但与创伤性脑损伤(TBI)无关。PVT 失败预测 SVT 失败,反之亦然。标准护理应包括所有临床评估中的 SVTs 和 PVTs,而不仅仅是神经心理评估,特别是在临床复杂人群中。