阴茎癌患者与基于人群的对照者的总生存率差异。
Differences in overall survival of penile cancer patients versus population-based controls.
机构信息
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.
Department of Urology, Medical University of Graz, Graz, Austria.
出版信息
Int J Urol. 2024 Mar;31(3):274-279. doi: 10.1111/iju.15346. Epub 2023 Nov 28.
PURPOSE
To assess whether 5-year overall survival (OS) of squamous cell carcinoma of the penis (SCCP) patients differs from age-matched male population-based controls.
METHODS
We relied on the Surveillance Epidemiology and End Results database (2004-2018) to identify newly diagnosed (2004-2013) SCCP patients. For each case, we simulated an age-matched control (Monte Carlo simulation), relying on the Social Security Administration (SSA) Life Tables with 5 years of follow-up. We compared OS between SCCP patients and population-based controls in a stage-specific fashion. Smoothed cumulative incidence plots displayed cancer-specific mortality (CSM) versus other-cause mortality (OCM).
RESULTS
Of 2282 SCCP patients, the stage distribution was as follows: stage I 976 (43%) versus stage II 826 (36%) versus stage III 302 (13%) versus stage IV 178 (8%). At 5 years, OS of SCCP patients versus age-matched population-based controls was as follows: stage I 63% versus 80% (Δ = 17%), stage II 50% versus 80% (Δ = 30%), stage III 39% versus 84% (Δ = 45%), stage IV 26% versus 87% (Δ = 61%). At 5 years, CSM versus OCM in SCCP patients according to stage was as follows: stage I 12% versus 24%, stage II 22% versus 28%, stage III 47% versus 14%, and stage IV 60% versus 14%.
CONCLUSION
SCCP patients exhibit worse OS across all stages. The difference in OS at 5 years between SCCP and age-matched male population-based controls ranged from 17% to 61%. At 5 years, CSM accounted for 12% to 60% of all deaths, across all stages.
目的
评估阴茎鳞状细胞癌 (SCCP) 患者的 5 年总生存率 (OS) 是否与年龄匹配的男性人群对照存在差异。
方法
我们依赖于监测、流行病学和最终结果数据库（2004-2018 年）来识别新诊断的 SCCP 患者（2004-2013 年）。对于每个病例，我们依靠社会保障管理局（SSA）生命表进行年龄匹配的模拟对照（蒙特卡罗模拟），并进行了 5 年的随访。我们以分期特异性的方式比较了 SCCP 患者和人群对照之间的 OS。平滑累积发病率图显示了癌症特异性死亡率 (CSM) 与其他原因死亡率 (OCM)。
结果
在 2282 例 SCCP 患者中，分期分布如下：I 期 976 例（43%），II 期 826 例（36%），III 期 302 例（13%），IV 期 178 例（8%）。在 5 年时，SCCP 患者与年龄匹配的人群对照的 OS 如下：I 期为 63%，80%（Δ=17%），II 期为 50%，80%（Δ=30%），III 期为 39%，84%（Δ=45%），IV 期为 26%，87%（Δ=61%）。在 5 年时，根据分期，SCCP 患者的 CSM 与 OCM 如下：I 期为 12%，24%，II 期为 22%，28%，III 期为 47%，14%，IV 期为 60%，14%。
结论
SCCP 患者在所有分期中均表现出较差的 OS。SCCP 患者与年龄匹配的男性人群对照在 5 年内的 OS 差异范围为 17%至 61%。在 5 年内，CSM 占所有死亡人数的 12%至 60%，各分期均如此。
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