Department of Entomology and Plant Pathology, University of Tennessee, Knoxville, Tennessee, USA.
Department of Entomology, University of Minnesota, St. Paul, Minnesota, USA.
Appl Environ Microbiol. 2023 Dec 21;89(12):e0164423. doi: 10.1128/aem.01644-23. Epub 2023 Nov 28.
is a major crop pest in the United States that is managed with transgenic corn and cotton that produce insecticidal proteins from the bacterium, (Bt). However, has evolved widespread resistance to the Cry proteins produced in Bt corn and cotton, leaving Vip3Aa as the only plant-incorporated protectant in Bt crops that consistently provides excellent control of . The benefits provided by Bt crops will be substantially reduced if widespread Vip3Aa resistance develops in field populations. Therefore, it is important to identify resistance alleles and mechanisms that contribute to Vip3Aa resistance to ensure that informed resistance management strategies are implemented. This study is the first report of reduced binding of Vip3Aa to midgut receptors associated with resistance.
是美国的一种主要作物害虫，通过种植转Bt 基因的玉米和棉花来防治，Bt 细菌能产生杀虫蛋白。然而， 已经对 Bt 玉米和棉花产生的 Cry 蛋白产生了广泛的抗性，使得 Vip3Aa 成为 Bt 作物中唯一持续提供对 优异控制的植物整合保护剂。如果 Vip3Aa 抗性在 田间种群中广泛发展，Bt 作物提供的益处将大大减少。因此，确定与 Vip3Aa 抗性相关的抗性等位基因和机制非常重要，以确保实施明智的抗性管理策略。本研究首次报道了 Vip3Aa 与与抗性相关的中肠受体的结合减少。
