Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cornea. 2024 Jul 1;43(7):835-843. doi: 10.1097/ICO.0000000000003429. Epub 2023 Nov 28.
The purpose of this study was to investigate the donor risk factors and environmental conditions associated with poor-quality corneas using the database of the Central Eye Bank of Iran over 4 years.
This cohort study was conducted on the recorded data of all donated corneas at the Central Eye Bank of Iran database from March 2018 to March 2022. Donors' characteristics and tissue variables were extracted from the database. The final corneal quality was determined based on slitlamp biomicroscopic observations and the results of specular microscopy. Environmental variables were also obtained from reliable resources. Risk factors for poor-quality corneas were calculated using logistic mixed-effect regression analysis. All analyses were performed with STATA 17.0. The significance level of 0.05 was considered for all the analyses.
The data of 20,625 eyes of 10,601 donors were evaluated. We found that donor age had an inverse correlation with endothelial cell density (r = -0.28, P < 0.001). The trend of donated corneal poor quality decreased between 2018 and 2021. Several factors, including intoxication (odds ratio [OR] = 1.29), obesity (OR = 1.34), diabetes mellitus (OR = 1.63), hypertension (OR = 1.52), and pseudophakic eyes (OR = 1.56), were associated with the poor quality of donated corneal tissues. The outdoor temperature over 26°C was associated with higher odds of poor corneal quality (OR = 1.31), whereas high relative humidity decreased the odds of poor corneal quality (OR = 0.82).
This study revealed that the cause of donor death, obesity, donor comorbidities, pseudophakia, and environmental factors could affect the corneal quality and make the donated corneas less suitable for transplantation.
本研究旨在利用伊朗中央眼库数据库，对 4 年来与角膜质量差相关的供体风险因素和环境条件进行研究。
这是一项基于队列的研究，对 2018 年 3 月至 2022 年 3 月间伊朗中央眼库数据库中所有捐献角膜的记录数据进行了研究。从数据库中提取供体特征和组织变量。最终的角膜质量根据裂隙灯生物显微镜观察和共焦显微镜的结果来确定。还从可靠的资源中获取了环境变量。使用逻辑混合效应回归分析计算了角膜质量差的风险因素。所有分析均采用 STATA 17.0 进行。所有分析的显著性水平均为 0.05。
共评估了 10601 名供体的 20625 只眼的数据。我们发现，供体年龄与内皮细胞密度呈负相关（r = -0.28，P < 0.001）。2018 年至 2021 年，捐献角膜质量差的趋势呈下降趋势。一些因素，包括中毒（比值比[OR] = 1.29）、肥胖（OR = 1.34）、糖尿病（OR = 1.63）、高血压（OR = 1.52）和假晶状体眼（OR = 1.56），与捐献角膜组织质量差有关。室外温度超过 26°C 与角膜质量差的可能性增加有关（OR = 1.31），而相对湿度高则降低了角膜质量差的可能性（OR = 0.82）。
本研究表明，供体死因、肥胖、供体合并症、假晶状体和环境因素可能会影响角膜质量，使捐献的角膜不太适合移植。
