Mirzoian R S, Gan'shina T S
Biull Eksp Biol Med. 1985 Jan;99(1):64-6.
Piracetam produces a more pronounced effect on cerebral circulation disturbed by hemorrhagic shock as compared with intact animals. Piracetam has a depressant effect on the nervous regulation of cerebral circulation by suppressing the reflex constriction of the vessels in both arterial systems of the brain. The cerebrovascular effects of piracetam are not mediated through the GABAergic bicuculline-sensitive mechanisms, which is supported by experiments where the drug exhibits its effects under the blockade of GABA receptors.
与正常动物相比，吡拉西坦对因失血性休克而紊乱的脑循环产生更显著的影响。吡拉西坦通过抑制脑动脉系统中血管的反射性收缩，对脑循环的神经调节产生抑制作用。吡拉西坦的脑血管效应不是通过对γ-氨基丁酸（GABA）能荷包牡丹碱敏感机制介导的，这一观点得到了在GABA受体阻断情况下该药物仍能发挥作用的实验支持。
