Recep Tayyip Erdoğan Üniversitesi Zihni Derin Yerleşkesi - Fener Mahallesi, Merkez/Rize, 53100, Turkey.
Kocaeli University Faculty of Medicine, Department of Ophthalmology, Kocaeli, 41100, Turkey.
Photodiagnosis Photodyn Ther. 2024 Feb;45:103899. doi: 10.1016/j.pdpdt.2023.103899. Epub 2023 Nov 26.
To investigate subclinical corneal changes using corneal topography in the evaluation of corneal curvature and specular microscopy in the evaluation of the endothelial layer after mild coronavirus disease 2019 (COVID-19).
In this prospective study, 112 eyes of 56 individuals with mild COVID-19 who recovered were investigated. Mean cell density (CD), mean coefficient of variation (CV), mean percentage of hexagonal cells, mean cell area (AVG), and central corneal thickness (CCT) were recorded from specular microscopy. K readings, including simulated keratometry flat (K1), simulated keratometry steep (K2), average keratometry (Kmean) and maximum keratometry (Kmax), pachymetric measurement and central corneal thickness (CCT), corneal volume (CV), topographic astigmatism (TA), curvature asymmetry front (CAf) and curvature asymmetry back (CAb) were recorded from corneal topography. Best corrected visual acuity (BCVA), spherical equivalant and biometric measurements were recorded.
The mean time interval between examinations before and after COVID-19 infection was approximately one year. Analysis of specular microscopy data showed a statistically significant change in all endothelial cell parameters (p<0.001) except the cell count (p = 0.358). The median (range) endothelial cell density (ECD) value was significantly lower after COVID-19 at 2356 (2289-2400) than before, when it was 2596 (2545-2640). Furthermore, CCT values showed a significant increase (p<0.001). The topographic values including K2, Kmax and TA and biometric measurements did not change. The Spherical Equivalant (SE) values showed significant myopic progression after COVID-19 (p<0.001).
Endothelial parameters changed more than the changes in corneal curvature and ocular biometric measurements after mild COVID-19. The decrease in endothelial cell number and hexagonality and increase in polymorphism after COVID-19 were striking.
在评估轻度 2019 年冠状病毒病（COVID-19）后角膜曲率时使用角膜地形学，以及在评估内皮层时使用共焦显微镜，研究亚临床角膜变化。
在这项前瞻性研究中，研究了 56 名轻度 COVID-19 康复患者的 112 只眼。从共焦显微镜记录平均细胞密度（CD）、平均变异系数（CV）、平均六边形细胞百分比、平均细胞面积（AVG）和中央角膜厚度（CCT）。从角膜地形图记录 K 读数，包括模拟角膜曲率平（K1）、模拟角膜曲率陡（K2）、平均角膜曲率（Kmean）和最大角膜曲率（Kmax）、厚度测量和中央角膜厚度（CCT）、角膜体积（CV）、角膜散光（TA）、前曲率不对称（CAf）和后曲率不对称（CAb）。记录最佳矫正视力（BCVA）、球镜等效和生物测量值。
两次 COVID-19 感染前后检查的平均时间间隔约为一年。共焦显微镜数据分析显示，除细胞计数外（p=0.358），所有内皮细胞参数均发生统计学显著变化（p<0.001）。感染 COVID-19 后内皮细胞密度（ECD）中位数（范围）为 2356（2289-2400），明显低于感染前的 2596（2545-2640）。此外，CCT 值显著增加（p<0.001）。角膜地形图值（包括 K2、Kmax 和 TA）和生物测量值没有变化。感染 COVID-19 后，等效球镜（SE）值显示出明显的近视进展（p<0.001）。
与轻度 COVID-19 后角膜曲率和眼生物测量值的变化相比，内皮参数的变化更大。感染 COVID-19 后内皮细胞数量减少、六边性降低以及多形性增加引人注目。
