QC Laboratory, Post-Harvest Technology, ICAR-Central Institute of Fisheries Education (CIFE), Mumbai, 400061, India.
Department of Biology, Eastern New Mexico University, Station 33, Portales, NM, 88130, USA.
Arch Microbiol. 2023 Nov 29;206(1):7. doi: 10.1007/s00203-023-03731-5.
The marine bacteria of the Vibrionaceae family are significant from the point of view of their role in the marine geochemical cycle, as well as symbionts and opportunistic pathogens of aquatic animals and humans. The well-known pathogens of this group, Vibrio cholerae, V. parahaemolyticus, and V. vulnificus, are responsible for significant morbidity and mortality associated with a range of infections from gastroenteritis to bacteremia acquired through the consumption of raw or undercooked seafood and exposure to seawater containing these pathogens. Although generally regarded as susceptible to commonly employed antibiotics, the antimicrobial resistance of Vibrio spp. has been on the rise in the last two decades, which has raised concern about future infections by these bacteria becoming increasingly challenging to treat. Diverse mechanisms of antimicrobial resistance have been discovered in pathogenic vibrios, the most important being the membrane efflux pumps, which contribute to antimicrobial resistance and their virulence, environmental fitness, and persistence through biofilm formation and quorum sensing. In this review, we discuss the evolution of antimicrobial resistance in pathogenic vibrios and some of the well-characterized efflux pumps' contributions to the physiology of antimicrobial resistance, host and environment survival, and their pathogenicity.
海洋弧菌科的海洋细菌在海洋地球化学循环中具有重要意义，它们还是水生动物和人类的共生体和机会致病菌。该组中众所周知的病原体霍乱弧菌、副溶血性弧菌和创伤弧菌可导致严重的发病率和死亡率，这些感染范围从肠胃炎到菌血症不等，其感染途径是食用生的或未煮熟的海鲜以及接触含有这些病原体的海水。尽管这些细菌通常被认为对常用抗生素敏感，但在过去二十年中，弧菌属的抗药性一直在上升，这引起了人们对未来这些细菌感染变得越来越难以治疗的担忧。在致病性弧菌中已经发现了多种抗药性机制，其中最重要的是膜外排泵，它通过生物膜形成和群体感应有助于抗药性及其毒力、环境适应性和持久性。在这篇综述中，我们讨论了致病性弧菌中抗药性的进化，以及一些特征明确的外排泵对抗药性生理学、宿主和环境生存以及它们的致病性的贡献。
