Liu Zhaoyun, Xu Xintong, Liu Hui, Zhao Xianghong, Yang Chun, Fu Rong
Department of Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Exp Hematol Oncol. 2023 Nov 28;12(1):99. doi: 10.1186/s40164-023-00456-5.
Multiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit MM patients. Immune checkpoints can negatively modulate the immune system and are closely associated with immune escape. Immune checkpoint-related therapy has attracted much attention and research in MM. However, the efficacy of those therapies need further improvements. There need more thoughts about the immune checkpoint to translate their use in clinical work. In our review, we aggregated the currently known immune checkpoints and their corresponding ligands, further more we propose various ways of potential translation applying treatment based on immune checkpoints for MM patients.
多发性骨髓瘤（MM）与免疫紊乱有关，最近的研究表明免疫疗法可使MM患者受益匪浅。免疫检查点可对免疫系统产生负调节作用，并与免疫逃逸密切相关。免疫检查点相关疗法在MM领域已引起广泛关注和研究。然而，这些疗法的疗效仍需进一步提高。在将免疫检查点应用于临床工作方面，仍需更多思考。在本综述中，我们汇总了目前已知的免疫检查点及其相应配体，此外，我们还提出了基于免疫检查点对MM患者进行潜在治疗转化的各种方法。
