纳洛酮可抑制麻醉犬冠状动脉闭塞和再灌注所诱发的心律失常。
Naloxone inhibits arrhythmias induced by coronary artery occlusion and reperfusion in anaesthetized dogs.
作者信息
Huang X D, Lee A Y, Wong T M, Zhan C Y, Zhao Y Y
出版信息
Br J Pharmacol. 1986 Mar;87(3):475-7. doi: 10.1111/j.1476-5381.1986.tb10186.x.
Abstract
The intravenous administration of naloxone 2 min before coronary artery occlusion in anaesthetized dogs reduced the incidence and severity of cardiac arrhythmias during coronary occlusion (20 min) and reperfusion (120 min) in a dose-related manner. It also reduced the mortality. At a dose of 1 mg kg-1 (the maximum dose used in this study) naloxone abolished the appearance of the life threatening ventricular fibrillation (VF) and ventricular tachycardia (VT) and as a consequence all dogs in this group survived. The results suggest a possible involvement of endogenous opioid peptides in arrhythmogenesis during coronary occlusion and reperfusion in the dog.
摘要
在麻醉犬冠状动脉闭塞前2分钟静脉注射纳洛酮，可剂量依赖性地降低冠状动脉闭塞（20分钟）和再灌注（120分钟）期间心律失常的发生率和严重程度。它还降低了死亡率。在1 mg/kg的剂量下（本研究中使用的最大剂量），纳洛酮消除了危及生命的心室颤动（VF）和室性心动过速（VT）的出现，因此该组所有犬均存活。结果表明内源性阿片肽可能参与犬冠状动脉闭塞和再灌注期间的心律失常发生。
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本文引用的文献
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