纳洛酮对犬心肌缺血及再灌注的立体特异性抗心律失常作用。
Stereospecific antiarrhythmic effects of naloxone against myocardial ischaemia and reperfusion in the dog.
作者信息
Lee A Y
机构信息
Department of Medical Research, Taichung Veterans General Hospital, Taiwan.
出版信息
Br J Pharmacol. 1992 Dec;107(4):1057-60. doi: 10.1111/j.1476-5381.1992.tb13406.x.
Abstract
- The effects of both the (-)- and (+)-stereoisomers of naloxone in anaesthetized dogs with arrhythmias induced by acute coronary artery occlusion followed by reperfusion were investigated. 2. Following coronary artery occlusion and reperfusion, all dogs in the control group developed ischaemia- and reperfusion-induced cardiac arrhythmias, bradycardia and hypotension. 3. The opiate antagonist (-)-naloxone prevented the arrhythmias, bradycardia and hypotension due to myocardial ischaemia and reperfusion. 4. The (+)-stereoisomer of naloxone, which is inactive as an opiate antagonist, was without beneficial effects. 5. These results indicate a possible involvement of endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion, mediated by opiate receptors through opiate antagonism.
摘要
- 研究了纳洛酮的（-）-和（+）-立体异构体对急性冠状动脉闭塞后再灌注诱发心律失常的麻醉犬的影响。2. 冠状动脉闭塞和再灌注后，对照组所有犬均出现缺血和再灌注诱发的心律失常、心动过缓和低血压。3. 阿片拮抗剂（-）-纳洛酮可预防心肌缺血和再灌注所致的心律失常、心动过缓和低血压。4. 作为阿片拮抗剂无活性的纳洛酮（+）-立体异构体没有有益作用。5. 这些结果表明内源性阿片肽可能参与了心肌缺血和再灌注所致的心脏效应，通过阿片受体介导阿片拮抗作用。
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