Brindley G S
Br J Pharmacol. 1986 Mar;87(3):495-500. doi: 10.1111/j.1476-5381.1986.tb10191.x.
Seven drugs that are known to relax smooth muscle (phenoxybenzamine, phentolamine, thymoxamine, imipramine, verapamil, papaverine, naftidrofuryl) caused erection when injected intracavernosally. Salbutamol, hydralazine, lignocaine and bupivacaine caused tumidity but not erection. Metaraminol and guanethidine caused shrinkage followed by tumidity. Neostigmine, atropine, propranolol and idazoxan had no effect in the doses tried. It is argued that the seven drugs that cause erection do so by relaxing vascular and trabecular smooth muscle within the cavernosal space, and that the two that cause shrinkage of the penis do so by constricting vascular and trabecular smooth muscle within the cavernosal space. It is argued that muscarinic and beta-adrenergic transmission play no important part in erectile mechanisms within the corpora cavernosa. Papaverine, phenoxybenzamine and metaraminol, given intracavernosally, are already used therapeutically. Uses are suggested for thymoxamine, phentolamine, verapamil and guanethidine.
已知有七种能使平滑肌松弛的药物（酚苄明、酚妥拉明、百里胺、丙咪嗪、维拉帕米、罂粟碱、萘呋胺酯）经海绵体内注射后可引起勃起。沙丁胺醇、肼屈嗪、利多卡因和布比卡因可引起肿胀但不能勃起。间羟胺和胍乙啶可使阴茎先收缩后肿胀。新斯的明、阿托品、普萘洛尔和咪唑克生在所试剂量下无作用。有人认为，引起勃起的七种药物是通过松弛海绵体内的血管和小梁平滑肌而起作用的，而导致阴茎收缩的两种药物是通过收缩海绵体内的血管和小梁平滑肌而起作用的。有人认为，毒蕈碱能和β-肾上腺素能传递在海绵体勃起机制中不起重要作用。罂粟碱、酚苄明和间羟胺经海绵体内注射已用于治疗。文中还提出了百里胺、酚妥拉明、维拉帕米和胍乙啶的用途。
