Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, M5S 3E5, Canada.
Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada.
Adv Sci (Weinh). 2024 Feb;11(8):e2306463. doi: 10.1002/advs.202306463. Epub 2023 Nov 28.
The complex anatomy and physiological barriers of the eye make delivering ocular therapeutics challenging. Generally, effective drug delivery to the eye is hindered by rapid clearance and limited drug bioavailability. Biomaterial-based approaches have emerged to enhance drug delivery to ocular tissues and overcome existing limitations. In this review, some of the most promising long-acting injectables (LAIs) in ocular drug delivery are explored, focusing on novel design strategies to improve therapeutic outcomes. LAIs are designed to enable sustained therapeutic effects, thereby extending local drug residence time and facilitating controlled and targeted drug delivery. Moreover, LAIs can be engineered to enhance drug targeting and penetration across ocular physiological barriers.
眼睛的复杂解剖结构和生理屏障使得眼部治疗药物的递送具有挑战性。一般来说，药物向眼部的有效递送受到快速清除和有限的药物生物利用度的阻碍。基于生物材料的方法已经出现，以增强药物向眼部组织的递送并克服现有局限性。在这篇综述中，探讨了眼部药物递送中一些最有前途的长效注射剂（LAIs），重点介绍了改善治疗效果的新颖设计策略。LAIs 的设计目的是实现持续的治疗效果，从而延长局部药物滞留时间，并促进药物的控制和靶向递送。此外，LAIs 可以被设计以增强药物在眼部生理屏障中的靶向和穿透。
