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Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research.

作者信息

Lu Yue, Cheng Dongfang, Niu Baohua, Wang Xiuzhi, Wu Xiaxia, Wang Aiping

机构信息

Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, School of Pharmacy, Yantai University, Yantai 264005, China.

Yantai Key Laboratory of Nanomedicine and Advanced Preparations, Yantai Institute of Materia Medica, Yantai 264000, China.

出版信息

Pharmaceuticals (Basel). 2023 Mar 17;16(3):454. doi: 10.3390/ph16030454.

DOI:10.3390/ph16030454
PMID:36986553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10058621/
Abstract

In recent years, biodegradable polymers have gained the attention of many researchers for their promising applications, especially in drug delivery, due to their good biocompatibility and designable degradation time. Poly (lactic-co-glycolic acid) (PLGA) is a biodegradable functional polymer made from the polymerization of lactic acid (LA) and glycolic acid (GA) and is widely used in pharmaceuticals and medical engineering materials because of its biocompatibility, non-toxicity, and good plasticity. The aim of this review is to illustrate the progress of research on PLGA in biomedical applications, as well as its shortcomings, to provide some assistance for its future research development.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/4f4eb4b3154c/pharmaceuticals-16-00454-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/8adf2bce1296/pharmaceuticals-16-00454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ea1eb26f5816/pharmaceuticals-16-00454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/e3106db73cce/pharmaceuticals-16-00454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/2ef68a9f1a79/pharmaceuticals-16-00454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/93a3b0cbe52d/pharmaceuticals-16-00454-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/c6c6c89cfa69/pharmaceuticals-16-00454-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/d09f85a0e5c3/pharmaceuticals-16-00454-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ce7c48b78065/pharmaceuticals-16-00454-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ee9da3bef46b/pharmaceuticals-16-00454-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/797b83ec49b5/pharmaceuticals-16-00454-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/471af9bee940/pharmaceuticals-16-00454-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/4f4eb4b3154c/pharmaceuticals-16-00454-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/8adf2bce1296/pharmaceuticals-16-00454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ea1eb26f5816/pharmaceuticals-16-00454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/e3106db73cce/pharmaceuticals-16-00454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/2ef68a9f1a79/pharmaceuticals-16-00454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/93a3b0cbe52d/pharmaceuticals-16-00454-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/c6c6c89cfa69/pharmaceuticals-16-00454-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/d09f85a0e5c3/pharmaceuticals-16-00454-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ce7c48b78065/pharmaceuticals-16-00454-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ee9da3bef46b/pharmaceuticals-16-00454-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/797b83ec49b5/pharmaceuticals-16-00454-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/471af9bee940/pharmaceuticals-16-00454-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/4f4eb4b3154c/pharmaceuticals-16-00454-g012.jpg

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本文引用的文献

[1]
A single-dose Qβ VLP vaccine against S100A9 protein reduces atherosclerosis in a preclinical model.

Adv Ther (Weinh). 2022-10

[2]
Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application.

Drug Deliv. 2022-12

[3]
Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering.

Int J Mol Sci. 2022-5-23

[4]
In vitro-in vivo correlation of PLGA microspheres: Effect of polymer source variation and temperature.

J Control Release. 2022-7

[5]
Microfluidic assisted synthesis of PLGA drug delivery systems.

RSC Adv. 2019-1-15

[6]
Targeting COPD with PLGA-Based Nanoparticles: Current Status and Prospects.

Biomed Res Int. 2022-3-11

[7]
Development of Peptide Targeted PLGA-PEGylated Nanoparticles Loading Licochalcone-A for Ocular Inflammation.

Pharmaceutics. 2022-1-26

[8]
Naringin as Sustained Delivery Nanoparticles Ameliorates the Anti-inflammatory Activity in a Freund's Complete Adjuvant-Induced Arthritis Model.

ACS Omega. 2021-10-22

[9]
Chitosan-Coated PLGA Nanoparticles Encapsulating Triamcinolone Acetonide as a Potential Candidate for Sustained Ocular Drug Delivery.

Pharmaceutics. 2021-9-30

[10]
Pyroptosis-Induced Inflammation and Tissue Damage.

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