• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

聚乳酸-乙醇酸共聚物的性质及聚乳酸-乙醇酸共聚物基生物可降解材料在生物医学研究中的进展

Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research.

作者信息

Lu Yue, Cheng Dongfang, Niu Baohua, Wang Xiuzhi, Wu Xiaxia, Wang Aiping

机构信息

Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, School of Pharmacy, Yantai University, Yantai 264005, China.

Yantai Key Laboratory of Nanomedicine and Advanced Preparations, Yantai Institute of Materia Medica, Yantai 264000, China.

出版信息

Pharmaceuticals (Basel). 2023 Mar 17;16(3):454. doi: 10.3390/ph16030454.

DOI:10.3390/ph16030454
PMID:36986553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10058621/
Abstract

In recent years, biodegradable polymers have gained the attention of many researchers for their promising applications, especially in drug delivery, due to their good biocompatibility and designable degradation time. Poly (lactic-co-glycolic acid) (PLGA) is a biodegradable functional polymer made from the polymerization of lactic acid (LA) and glycolic acid (GA) and is widely used in pharmaceuticals and medical engineering materials because of its biocompatibility, non-toxicity, and good plasticity. The aim of this review is to illustrate the progress of research on PLGA in biomedical applications, as well as its shortcomings, to provide some assistance for its future research development.

摘要

近年来，可生物降解聚合物因其具有广阔的应用前景，尤其是在药物递送方面，受到了众多研究人员的关注，这得益于它们良好的生物相容性和可设计的降解时间。聚乳酸-乙醇酸共聚物（PLGA）是一种由乳酸（LA）和乙醇酸（GA）聚合而成的可生物降解功能聚合物，因其生物相容性、无毒性和良好的可塑性，被广泛应用于制药和医学工程材料领域。本综述的目的是阐述PLGA在生物医学应用方面的研究进展及其不足之处，为其未来的研究发展提供一些帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/4f4eb4b3154c/pharmaceuticals-16-00454-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/8adf2bce1296/pharmaceuticals-16-00454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ea1eb26f5816/pharmaceuticals-16-00454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/e3106db73cce/pharmaceuticals-16-00454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/2ef68a9f1a79/pharmaceuticals-16-00454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/93a3b0cbe52d/pharmaceuticals-16-00454-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/c6c6c89cfa69/pharmaceuticals-16-00454-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/d09f85a0e5c3/pharmaceuticals-16-00454-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ce7c48b78065/pharmaceuticals-16-00454-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ee9da3bef46b/pharmaceuticals-16-00454-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/797b83ec49b5/pharmaceuticals-16-00454-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/471af9bee940/pharmaceuticals-16-00454-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/4f4eb4b3154c/pharmaceuticals-16-00454-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/8adf2bce1296/pharmaceuticals-16-00454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ea1eb26f5816/pharmaceuticals-16-00454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/e3106db73cce/pharmaceuticals-16-00454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/2ef68a9f1a79/pharmaceuticals-16-00454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/93a3b0cbe52d/pharmaceuticals-16-00454-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/c6c6c89cfa69/pharmaceuticals-16-00454-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/d09f85a0e5c3/pharmaceuticals-16-00454-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ce7c48b78065/pharmaceuticals-16-00454-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/ee9da3bef46b/pharmaceuticals-16-00454-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/797b83ec49b5/pharmaceuticals-16-00454-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/471af9bee940/pharmaceuticals-16-00454-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c3d/10058621/4f4eb4b3154c/pharmaceuticals-16-00454-g012.jpg

相似文献

1
Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research.聚乳酸-乙醇酸共聚物的性质及聚乳酸-乙醇酸共聚物基生物可降解材料在生物医学研究中的进展
Pharmaceuticals (Basel). 2023 Mar 17;16(3):454. doi: 10.3390/ph16030454.
2
Recent applications of PLGA based nanostructures in drug delivery.基于聚乳酸-乙醇酸共聚物的纳米结构在药物传递中的最新应用。
Colloids Surf B Biointerfaces. 2017 Nov 1;159:217-231. doi: 10.1016/j.colsurfb.2017.07.038. Epub 2017 Jul 28.
3
Customizing poly(lactic-co-glycolic acid) particles for biomedical applications.定制聚（乳酸-共-乙醇酸）颗粒用于生物医学应用。
Acta Biomater. 2018 Jun;73:38-51. doi: 10.1016/j.actbio.2018.04.006. Epub 2018 Apr 11.
4
Redefining the importance of polylactide-co-glycolide acid (PLGA) in drug delivery.重新定义聚乳酸-共-乙醇酸（PLGA）在药物传递中的重要性。
Ann Pharm Fr. 2022 Sep;80(5):603-616. doi: 10.1016/j.pharma.2021.11.009. Epub 2021 Dec 9.
5
Progress in the drug encapsulation of poly(lactic--glycolic acid) and folate-decorated poly(ethylene glycol)-poly(lactic--glycolic acid) conjugates for selective cancer treatment.聚（乳酸-乙醇酸）和叶酸修饰的聚（乙二醇）-聚（乳酸-乙醇酸）缀合物用于选择性癌症治疗的药物包封研究进展。
J Mater Chem B. 2022 Jun 8;10(22):4127-4141. doi: 10.1039/d2tb00469k.
6
Synthesis, characterization, and evaluation of paclitaxel loaded in six-arm star-shaped poly(lactic-co-glycolic acid).六臂星形聚（乳酸-共-乙醇酸）载紫杉醇的合成、表征及评价。
Int J Nanomedicine. 2013;8:4315-26. doi: 10.2147/IJN.S51629. Epub 2013 Nov 7.
7
Generational Biodegradable and Regenerative Polyphosphazene Polymers and their Blends with Poly (lactic-co-glycolic acid).可降解和可再生的聚磷腈聚合物及其与聚（乳酸-乙醇酸共聚物）的共混物
Prog Polym Sci. 2019 Nov;98. doi: 10.1016/j.progpolymsci.2019.101146. Epub 2019 Aug 9.
8
Improved biocompatibility of poly(lactic-co-glycolic acid) orv and poly-L-lactic acid blended with nanoparticulate amorphous calcium phosphate in vascular stent applications.改善聚（乳酸-共-乙醇酸）或聚-L-乳酸与纳米无定形磷酸钙在血管支架应用中的生物相容性。
J Biomed Nanotechnol. 2014 Jun;10(6):900-10. doi: 10.1166/jbn.2014.1856.
9
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier.聚乳酸-乙醇酸共聚物（PLGA）作为可生物降解的控释药物载体。
Polymers (Basel). 2011 Sep 1;3(3):1377-1397. doi: 10.3390/polym3031377. Epub 2011 Aug 26.
10
Influence of the microencapsulation method and peptide loading on poly(lactic acid) and poly(lactic-co-glycolic acid) degradation during in vitro testing.微囊化方法和肽负载对聚乳酸和聚乳酸-乙醇酸共聚物体外测试期间降解的影响。
J Control Release. 1998 Feb 12;51(2-3):327-41. doi: 10.1016/s0168-3659(97)00188-0.

引用本文的文献

1
Phages and Control of -Associated Human, Animal, and Plant Diseases.噬菌体与人类、动物和植物相关疾病的控制
Microorganisms. 2025 Aug 11;13(8):1873. doi: 10.3390/microorganisms13081873.
2
Next-Generation Wound Healing Materials: Role of Biopolymers and Their Composites.下一代伤口愈合材料：生物聚合物及其复合材料的作用。
Polymers (Basel). 2025 Aug 19;17(16):2244. doi: 10.3390/polym17162244.
3
Neuroregenerative and neuroprotective effects of bioengineered scaffolds in spinal cord injury: a systematic review of preclinical and early phase clinical studies.

本文引用的文献

1
A single-dose Qβ VLP vaccine against S100A9 protein reduces atherosclerosis in a preclinical model.一种针对S100A9蛋白的单剂量Qβ病毒样颗粒疫苗可在临床前模型中减轻动脉粥样硬化。
Adv Ther (Weinh). 2022 Oct;5(10). doi: 10.1002/adtp.202200092. Epub 2022 Jul 7.
2
Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application.细胞膜伪装的 PLGA 仿生系统，用于多种生物医学应用。
Drug Deliv. 2022 Dec;29(1):2296-2319. doi: 10.1080/10717544.2022.2100010.
3
Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering.
生物工程支架在脊髓损伤中的神经再生和神经保护作用：对临床前和早期临床研究的系统评价
Spinal Cord. 2025 Aug 23. doi: 10.1038/s41393-025-01114-9.
4
Advanced Bioactive Polymers and Materials for Nerve Repair: Strategies and Mechanistic Insights.用于神经修复的先进生物活性聚合物和材料：策略与机制洞察
J Funct Biomater. 2025 Jul 9;16(7):255. doi: 10.3390/jfb16070255.
5
Tissue Regeneration of Radiation-Induced Skin Damages Using Protein/Polysaccharide-Based Bioengineered Scaffolds and Adipose-Derived Stem Cells: A Review.使用基于蛋白质/多糖的生物工程支架和脂肪干细胞对辐射诱导的皮肤损伤进行组织再生：综述
Int J Mol Sci. 2025 Jul 4;26(13):6469. doi: 10.3390/ijms26136469.
6
A Review on Novel Formulations and Delivery Systems of Botanical Insecticides for Enhanced Efficacy.关于提高药效的植物源杀虫剂新型制剂与给药系统的综述
Neotrop Entomol. 2025 Jul 10;54(1):81. doi: 10.1007/s13744-025-01290-6.
7
Revolutionizing Diabetes Management Through Nanotechnology-Driven Smart Systems.通过纳米技术驱动的智能系统革新糖尿病管理。
Pharmaceutics. 2025 Jun 13;17(6):777. doi: 10.3390/pharmaceutics17060777.
8
Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering.术后粘连屏障及子宫组织工程中的生物材料
Gels. 2025 Jun 9;11(6):441. doi: 10.3390/gels11060441.
9
Bioactive Hydrogel Scaffolds Integrating Chitosan, Silk Fibroin, and Extract for Enhanced Cartilage Tissue Regeneration.整合壳聚糖、丝素蛋白和提取物以促进软骨组织再生的生物活性水凝胶支架
Polymers (Basel). 2025 May 20;17(10):1409. doi: 10.3390/polym17101409.
10
Recent advances in the application of nanotechnology in joint arthroplasty: a narrative review.纳米技术在关节置换术中应用的最新进展：一项叙述性综述。
Ann Jt. 2025 Apr 22;10:13. doi: 10.21037/aoj-24-50. eCollection 2025.
3D 打印聚乳酸-乙醇酸共聚物支架在骨组织工程中的应用。
Int J Mol Sci. 2022 May 23;23(10):5831. doi: 10.3390/ijms23105831.
4
In vitro-in vivo correlation of PLGA microspheres: Effect of polymer source variation and temperature.PLGA 微球的体外-体内相关性：聚合物来源变化和温度的影响。
J Control Release. 2022 Jul;347:347-355. doi: 10.1016/j.jconrel.2022.05.014. Epub 2022 May 18.
5
Microfluidic assisted synthesis of PLGA drug delivery systems.微流控辅助合成聚乳酸-羟基乙酸共聚物药物递送系统
RSC Adv. 2019 Jan 15;9(4):2055-2072. doi: 10.1039/c8ra08972h. eCollection 2019 Jan 14.
6
Targeting COPD with PLGA-Based Nanoparticles: Current Status and Prospects.基于聚乳酸-羟基乙酸共聚物的纳米颗粒靶向慢性阻塞性肺疾病：现状与前景
Biomed Res Int. 2022 Mar 11;2022:5058121. doi: 10.1155/2022/5058121. eCollection 2022.
7
Development of Peptide Targeted PLGA-PEGylated Nanoparticles Loading Licochalcone-A for Ocular Inflammation.用于眼部炎症的载有甘草查尔酮A的肽靶向聚乳酸-羟基乙酸共聚物-聚乙二醇化纳米颗粒的研发
Pharmaceutics. 2022 Jan 26;14(2):285. doi: 10.3390/pharmaceutics14020285.
8
Naringin as Sustained Delivery Nanoparticles Ameliorates the Anti-inflammatory Activity in a Freund's Complete Adjuvant-Induced Arthritis Model.柚皮苷作为缓释纳米颗粒改善弗氏完全佐剂诱导的关节炎模型中的抗炎活性。
ACS Omega. 2021 Oct 22;6(43):28630-28641. doi: 10.1021/acsomega.1c03066. eCollection 2021 Nov 2.
9
Chitosan-Coated PLGA Nanoparticles Encapsulating Triamcinolone Acetonide as a Potential Candidate for Sustained Ocular Drug Delivery.包裹曲安奈德的壳聚糖包衣聚乳酸-羟基乙酸共聚物纳米粒作为眼用药物持续递送的潜在候选物
Pharmaceutics. 2021 Sep 30;13(10):1590. doi: 10.3390/pharmaceutics13101590.
10
Pyroptosis-Induced Inflammation and Tissue Damage.细胞焦亡诱导的炎症与组织损伤。
J Mol Biol. 2022 Feb 28;434(4):167301. doi: 10.1016/j.jmb.2021.167301. Epub 2021 Oct 13.