Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
School of Clinical Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Future Oncol. 2023 Nov;19(36):2405-2416. doi: 10.2217/fon-2023-0685. Epub 2023 Nov 29.
This single-center retrospective study compared the efficacy of breast-conserving therapy along with axillary lymph node dissection (ALND) with mastectomy and ALND with regard to survival of Chinese patients with occult breast cancer. Univariate Kaplan-Meier analysis and multivariate Cox proportional hazards model were used to compare treatments and prognosis. A total of 111 patients with a median follow-up of 72.9 months were included. 39 patients with mastectomy + ALND had better disease-free survival than 72 patients with breast-conserving therapy + ALND (HR = 0.31; p = 0.012). Patients with radiotherapy demonstrated inferior survival for both overall survival (HR = 2.67; p = 0.071) and disease-free survival (HR = 5.35; p = 0.002). Surgical strategies and radiotherapy remained significantly predictive of better disease-free survival in multivariate analyses. Mastectomy and ALND demonstrate superior disease-free prognosis compared with breast-conserving therapy and ALND in occult breast cancer.
这项单中心回顾性研究比较了保乳治疗联合腋窝淋巴结清扫术（ALND）与乳房切除术和 ALND 对中国隐匿性乳腺癌患者生存的疗效。采用单因素 Kaplan-Meier 分析和多因素 Cox 比例风险模型比较治疗方法和预后。共纳入 111 例患者，中位随访 72.9 个月。39 例接受乳房切除术+ALND 的患者无病生存率优于 72 例接受保乳治疗+ALND 的患者（HR=0.31；p=0.012）。接受放疗的患者总生存（HR=2.67；p=0.071）和无病生存（HR=5.35；p=0.002）均较差。多因素分析显示，手术策略和放疗仍然是无病生存的显著预测因素。在隐匿性乳腺癌中，乳房切除术和 ALND 比保乳治疗和 ALND 具有更好的无病预后。
