Mirski M A, McKeon A C, Ferrendelli J A
Brain Res. 1986 Nov 12;397(2):377-80. doi: 10.1016/0006-8993(86)90642-6.
Injection of gamma-vinyl aminobutyric acid (GVG) into the anterior thalamus protected rats against pentylenetetrazol (PTZ) seizures but not against maximal electroshock (MES) seizures. Injection of GVG into the substantia nigra protected against MES seizures but not against PTZ seizures. Both types of seizures were prevented by injections into both of the above brain regions. These data indicate that separate neuronal circuits mediate PTZ and MES seizures.
将γ-乙烯基氨基丁酸（GVG）注入丘脑前部可保护大鼠免受戊四氮（PTZ）诱发的癫痫发作，但不能保护其免受最大电休克（MES）诱发的癫痫发作。将GVG注入黑质可保护大鼠免受MES诱发的癫痫发作，但不能保护其免受PTZ诱发的癫痫发作。同时向上述两个脑区注射GVG可预防两种类型的癫痫发作。这些数据表明，不同的神经元回路介导PTZ和MES诱发的癫痫发作。
