Jordan Bertrand
Biologiste, généticien et immunologiste, Président d'Aprogène (Association pour la promotion de la Génomique), 13007 Marseille, France.
Med Sci (Paris). 2023 Nov;39(11):885-887. doi: 10.1051/medsci/2023158. Epub 2023 Nov 29.
Systematic screening for specific cancers has been shown to reduce cancer-specific mortality, but has not demonstrated an effect on all-cause mortality. This paradox is due to minor but frequent risks of screening bearing on a large population, and also to the small beneficial effect expected even if screening is highly efficient. Upcoming multicancer detection approaches should allow a better detection of the effect (if any) of screening on all-cause mortality.
系统筛查特定癌症已被证明可降低癌症特异性死亡率，但尚未显示对全因死亡率有影响。这种矛盾现象归因于筛查对大量人群存在的虽小但频繁的风险，也归因于即便筛查效率很高预期的有益效果也很小。即将出现的多癌检测方法应能更好地检测筛查对全因死亡率的影响（如果有影响的话）。
