成年后患卵巢癌的早期生命期体力活动风险。
Early life physical activity and risk of ovarian cancer in adulthood.
机构信息
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Department of Health Education and Behavior, University of Florida, Gainesville, Florida, USA.
出版信息
Int J Cancer. 2021 Dec 15;149(12):2045-2051. doi: 10.1002/ijc.33760. Epub 2021 Aug 21.
Emerging data suggest that exposures in early life may affect ovarian development and contribute to ovarian cancer risk. We evaluated the association between early life physical activity and risk of ovarian cancer in adulthood in two large prospective cohorts, the Nurses' Health Study (NHS) and NHSII. In total, analyses included 28 232 NHS participants (followed from 2004 to 2016) and 56 553 NHSII participants (followed from 1997 to 2017). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of ovarian cancer overall and by early life body mass index (BMI). Neither physical activity at ages 12-13, 14-17 or 18-22 years nor average physical activity across these three periods was associated with ovarian cancer risk overall (≥78 vs <24 MET-h/wk, HRs = 1.34, 1.21, 1.08 and 1.24, respectively), or by categories of early life BMI (P ≥ .44). No association was observed with the risk of high-grade serous or poorly differentiated tumors or postmenopausal ovarian cancer. Overall, early life physical activity was not clearly related to ovarian cancer risk during adulthood.
新出现的数据表明，生命早期的暴露可能会影响卵巢发育并导致卵巢癌风险增加。我们在两项大型前瞻性队列研究——护士健康研究（NHS）和 NHSII 中评估了生命早期体力活动与成年后患卵巢癌的风险之间的关联。共有 28232 名 NHS 参与者（从 2004 年随访至 2016 年）和 56553 名 NHSII 参与者（从 1997 年随访至 2017 年）纳入分析。使用 Cox 比例风险模型估计了总体卵巢癌风险以及按生命早期体重指数（BMI）分层的卵巢癌风险的风险比（HR）和 95%置信区间（CI）。12-13 岁、14-17 岁或 18-22 岁时的体力活动水平以及这三个时期的平均体力活动水平均与总体卵巢癌风险（≥78 与<24 MET-h/wk，HRs=1.34、1.21、1.08 和 1.24）或生命早期 BMI 分类无关（P≥.44）。与高级别浆液性或低分化肿瘤或绝经后卵巢癌风险之间也未观察到关联。总体而言，生命早期的体力活动与成年后患卵巢癌的风险之间似乎没有明确的关系。
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