The influence of suckling on the hypothalamic and pituitary secretion of immunoreactive alpha-melanocyte stimulating hormone.

The effect of suckling on the secretion of alpha-melanocyte stimulating hormone (alpha-MSH) from the hypothalamus and pituitary was determined by a specific radioimmunoassay. There was an increase in the neurointermediate lobe (NIL) content of alpha-MSH 1 h after the onset of suckling. The values were restored to control levels within 3 h. The anterior lobe content of alpha-MSH was not affected by suckling. Plasma alpha-MSH levels were also unaffected by suckling, indicating that suckling probably affects the synthesis of NIL alpha-MSH, and not its release. Suckling lowered the alpha-MSH content in the mediobasal hypothalamus of lactating rats, and had no effect on the median eminence content of this peptide. In vitro, hypothalami from lactating rats released more alpha-MSH than hypothalami of random cycling females under basal, and stimulated (56 mM potassium) conditions. These results suggest that hypothalamic alpha-MSH may play a role in mediating some of the hormonal changes occurring during lactation.