Hinton V, Rosofsky M, Granger J, Geary N
Brain Res Bull. 1986 Nov;17(5):615-9. doi: 10.1016/0361-9230(86)90192-9.
Pancreatic glucagon (PG), cholecystokinin (CCK), and bombesin (BBS) were injected individually and in combination before nondeprived rats were offered condensed milk test meals. Peptide doses that were individually below the threshold for reliable inhibition of meal size (0.15 microgram/kg CCK, 0.75 microgram/kg BBS, 100 micrograms/kg PG) combined to inhibit meal size 19-40%. The inhibitions produced by combinations including CCK were 16-21% more than the sum of the inhibitions elicited by individual injections. This indicates a potentiation of inhibition. In contrast, when peptide doses were increased, the inhibitory effects of the combinations were similar to the sum of the individual injections. None of the peptide treatments disrupted the normal behavioral sequence of postprandial satiety, and they did not reliably affect water intake in water-deprived rats. We conclude that exogenous CCK, BBS, and PG can interact to potentiate postprandial satiety.
在未禁食的大鼠食用炼乳测试餐之前，分别单独注射和联合注射胰高血糖素（PG）、胆囊收缩素（CCK）和蛙皮素（BBS）。单独使用时剂量低于可靠抑制进食量阈值的肽（0.15微克/千克CCK、0.75微克/千克BBS、100微克/千克PG）联合使用时可抑制进食量19% - 40%。包含CCK的联合注射产生的抑制作用比单独注射引起的抑制作用之和高16% - 21%。这表明存在抑制作用的增强。相反，当肽剂量增加时，联合注射的抑制作用与单独注射的抑制作用之和相似。没有一种肽处理会破坏餐后饱腹感的正常行为顺序，并且它们对缺水大鼠的饮水量没有可靠影响。我们得出结论，外源性CCK、BBS和PG可以相互作用以增强餐后饱腹感。
