Stein L J, Woods S C
Peptides. 1981 Winter;2(4):431-6. doi: 10.1016/s0196-9781(81)80100-3.
The satiating effects of cholecystokinin-octapeptide (CCK-8) and bombesin (BBS) when injected alone and in combination were compared in intact rats. When injected alone, both CCK-8 and BBS elicited a dose-related decrease of 30-minute food intake. Injections of BBS were less potent than the equivalent doses of CCK-8 in producing satiety. BBS reached an asymptotic level of suppression of approximately 40 percent at a dose of 2 micrograms/kg, whereas injections of 4 micrograms/kg of CCK-8 resulted in a 72 percent suppression of food intake. When the two peptides were administered in a single injection, the resulting suppression of food intake was equivalent to that which would be predicted if their effects were completely additive. These results support the hypothesis that CCK-8 and BBS act via independent mechanisms to induce satiety. A preliminary model of peptidergic satiety, based on this hypothesis, is proposed.
在完整大鼠中比较了单独注射和联合注射胆囊收缩素八肽（CCK - 8）和蛙皮素（BBS）的饱腹感效应。单独注射时，CCK - 8和BBS均引起30分钟食物摄入量与剂量相关的减少。在产生饱腹感方面，BBS的效力低于等效剂量的CCK - 8。BBS在剂量为2微克/千克时达到约40%的渐近抑制水平，而注射4微克/千克的CCK - 8导致食物摄入量减少72%。当两种肽单次注射时，由此产生的食物摄入量抑制相当于如果它们的作用完全相加所预测的抑制。这些结果支持CCK - 8和BBS通过独立机制诱导饱腹感的假设。基于该假设，提出了一个肽能饱腹感的初步模型。
