Department of Biology and Chemistry, Islamic Azad University of Medical Science Branch, Tehran, Iran.
Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA.
Asian Pac J Cancer Prev. 2023 Nov 1;24(11):3985-3991. doi: 10.31557/APJCP.2023.24.11.3985.
Cancer poses a significant challenge in modern medicine, standing as the primary cause of death in many countries, second only to cardiovascular diseases. Among the various treatments available, carboplatin, a chemotherapy drug, is employed for specific cancer types, including brain carcinoma. The main objective of this investigation is to enhance the therapeutic efficacy of carboplatin by utilizing niosomal nanocarriers.
We synthesized nanoniosomal carboplatin using the reverse-phase evaporation technique and conducted an assessment of its particle size, zeta potential, and drug-release properties. Subsequently, we evaluated the cytotoxicity of nanoniosomal carboplatin using the C6 rat glioma cell line.
Our research revealed that these niosomal nanoparticles possessed a particle size of 290.5±5.5 nm and a zeta potential of -21.7±7.4 mV. The amount of encapsulated drug and drug loading level were found to be 60.2±2.3% and 2.5±1.1%, respectively. Importantly, the cytotoxic impact of these nanoniosomes on the C6 rat glioma cell line exhibited a significant increase compared to the free drug (P<0.05).
Based on our discoveries, it is evident that carboplatin niosomal nanocarriers hold potential as an innovative approach to chemotherapy for brain cancer therapy.
癌症是现代医学面临的重大挑战，在许多国家是主要死亡原因，仅次于心血管疾病。在现有的各种治疗方法中，卡铂是一种化疗药物，用于治疗特定类型的癌症，包括脑癌。本研究的主要目的是通过使用脂质体纳米载体来提高卡铂的治疗效果。
我们使用反相蒸发技术合成了纳米脂质体卡铂，并对其粒径、zeta 电位和药物释放性能进行了评估。然后，我们使用 C6 大鼠神经胶质瘤细胞系评估了纳米脂质体卡铂的细胞毒性。
我们的研究表明，这些脂质体纳米颗粒的粒径为 290.5±5.5nm，zeta 电位为-21.7±7.4mV。包封药物的量和载药量分别为 60.2±2.3%和 2.5±1.1%。重要的是，这些纳米脂质体对 C6 大鼠神经胶质瘤细胞系的细胞毒性作用与游离药物相比显著增加（P<0.05）。
根据我们的发现，卡铂脂质体纳米载体作为脑癌治疗的化疗新方法具有潜力。
