Angel I, Kiss A, Stivers J A, Skirboll L, Crawley J N, Paul S M
Brain Res Bull. 1986 Dec;17(6):873-7. doi: 10.1016/0361-9230(86)90101-2.
The distribution of low-affinity sodium-sensitive binding sites of [3H]mazindol were studied in rat hypothalamic nuclei. Using microdissection methods, it was demonstrated that the highest level of [3H]mazindol binding is localized to the paraventricular nucleus (PVN) and the lowest binding is observed in the lateral hypothalamus. Following food deprivation, a significant decrease in [3H]mazindol binding in the PVN and ventromedial hypothalamus (VHM) were observed. Refeeding food-deprived rats resulted in restoration of the level of binding in the PVN, and this was correlated with changes in blood glucose levels. Thus, changes in the binding of [3H]mazindol in the PVN may reflect local changes in glucose levels. In related studies, the involvement of the PVN in the regulation of food deprivation or 2-deoxyglucose (2-DG)-induced food intake was studied. Application of amphetamine (20 micrograms) into the PVN had no effect on food deprivation induced feeding, but significantly inhibited 2-DG induced (glucoprivic) feeding. The PVN may play an important role in the glucostatic regulation of feeding and in mediating the anorectic action of amphetamine and related anorectic drugs on glucoprivic feeding.
研究了[3H]马吲哚低亲和力钠敏感结合位点在大鼠下丘脑核团中的分布。采用显微解剖方法表明，[3H]马吲哚结合水平最高的区域位于室旁核（PVN），而在下丘脑外侧观察到的结合水平最低。禁食后，观察到PVN和腹内侧下丘脑（VHM）中[3H]马吲哚结合显著减少。给禁食大鼠重新喂食导致PVN中结合水平恢复，这与血糖水平变化相关。因此，PVN中[3H]马吲哚结合的变化可能反映了局部葡萄糖水平的变化。在相关研究中，研究了PVN在禁食或2-脱氧葡萄糖（2-DG）诱导的食物摄入调节中的作用。向PVN注射苯丙胺（20微克）对禁食诱导的进食没有影响，但显著抑制2-DG诱导的（糖缺乏性）进食。PVN可能在进食的糖稳态调节以及介导苯丙胺和相关厌食药物对糖缺乏性进食的厌食作用中发挥重要作用。
