Fukuda M, Ono T, Nishino H, Nakamura K
Brain Res Bull. 1986 Dec;17(6):879-83. doi: 10.1016/0361-9230(86)90102-4.
Single neuron activity was recorded from monkey lateral hypothalamus to investigate neuronal events correlated with operant bar press feeding behavior. The behavioral paradigm was divided into three phase: visual (discrimination), bar press (procurement), and ingestion (consummatory). Of 669 neurons tested, 158 (24%) responded in one or more phases. During the visual phase, 106 neurons (16%) responded. Of 80 neurons that responded in the visual phase and were tested systematically, 33 (41%, 33/80) responded selectively to the sight of food or nonfood objects associated with a juice reward, but not to the sight of nonfood or objects associated with aversive saline. Neuronal activity related to discrimination was modulated by satiation and learning (i.e., acquisition and extinction). During the bar press phase, 51 neurons (7.6%) responded. These responded tonically during the early or late stage of the bar press period, but did not depend on individual bar pressing motions. During ingestion, 90 neurons (13%) responded. The ingestion response was modulated by palatability of food and satiation. Data suggest that the LHA is deeply involved in operant feeding behavior; discrimination of food, drive to get food, and perception of reward, all of which are affected by learning and internal states such as hunger and satiety.
记录了猴子外侧下丘脑的单个神经元活动，以研究与操作性压杆进食行为相关的神经元事件。行为范式分为三个阶段：视觉（辨别）、压杆（获取）和摄取（ consummatory ）。在测试的669个神经元中，158个（24%）在一个或多个阶段有反应。在视觉阶段，106个神经元（16%）有反应。在视觉阶段有反应并经过系统测试的80个神经元中，33个（41%，33/80）对与果汁奖励相关的食物或非食物物体的视觉有选择性反应，但对与厌恶盐水相关的非食物或物体的视觉没有反应。与辨别相关的神经元活动受饱足和学习（即获取和消退）的调节。在压杆阶段，51个神经元（7.6%）有反应。这些神经元在压杆期的早期或晚期持续反应，但不依赖于单个压杆动作。在摄取过程中，90个神经元（13%）有反应。摄取反应受食物适口性和饱足的调节。数据表明，外侧下丘脑深度参与操作性进食行为；食物辨别、获取食物的驱动力和奖励感知，所有这些都受学习和饥饿与饱足等内部状态的影响。
