猴子操作性进食行为中与奖赏相关的神经元反应的阿片机制。

Opiate mechanism in reward-related neuronal responses during operant feeding behavior of the monkey.

作者信息

Oomura Y, Nishino H, Aou S, Lénárd L

出版信息

Brain Res. 1986 Feb 19;365(2):335-9. doi: 10.1016/0006-8993(86)91645-8.

Abstract

Reward-related neuronal activity and its modulation by morphine and naloxone was investigated by extracellular single neuron recording and electrophoretic application of drugs in the lateral hypothalamus, during operant feeding of the monkey. Morphine-sensitive neurons responded more often during bar press and ingestion-reward phases. Naloxone blocked only ingestion-reward responses, especially the inhibitory ones. The results suggest that the central opiate system can be involved in reward-related neuronal responses in the lateral hypothalamic area of the monkey.

摘要

在猴子的操作性进食过程中，通过细胞外单神经元记录以及在下丘脑外侧电泳给药，研究了与奖赏相关的神经元活动及其受吗啡和纳洛酮的调节。对吗啡敏感的神经元在压杆和摄入奖赏阶段反应更为频繁。纳洛酮仅阻断摄入奖赏反应，尤其是抑制性反应。结果表明，中枢阿片系统可能参与猴子下丘脑外侧区与奖赏相关的神经元反应。