Department of Ophthalmology (T.I., T.S.), Toho University, Tokyo, Japan; OPHTECS Corporation (K.Y.), Kobe Research Center, Kobe, Japan; Ishizuchi Eye Clinic (T.S.), Ehime, Japan; Department of Innovative Visual Science (S.K.), Osaka University Graduate School of Medicine, Osaka, Japan; and Department of Ophthalmology (S.K.), Osaka University Graduate School of Medicine, Osaka, Japan.
Eye Contact Lens. 2024 Feb 1;50(2):91-101. doi: 10.1097/ICL.0000000000001060. Epub 2023 Nov 29.
Half of the individuals who wear contact lenses use reusable lenses that require proper care. Improper contact lens (CL) care and using inadequate disinfecting solutions can lead to lens contamination, CL-related microbial keratitis, and Acanthamoeba keratitis. Oxidative disinfecting solutions, such as hydrogen peroxide, show higher efficacy than multipurpose solutions. Povidone-iodine (PVP-I), an oxidative disinfectant used in ophthalmic surgery, has been proven to be safe and effective. The PVP-I system, a CL disinfecting solution developed in Japan, has demonstrated excellent antimicrobial and antiviral properties. Although CL discomfort does not have a risk of ocular disorders with poor visual prognosis, such as keratitis, CL discomfort can still lead to lens dropout and thus needs to be addressed. To mitigate CL discomfort, it is essential to use disinfecting solutions containing surfactants and wetting agents that improve wettability of the lens surface. A CL solution containing hyaluronic acid derivatives (HADs) as wetting agents that permanently adhere to the lens surface to improve wettability of the lens surface was developed in Japan. There is potential for HAD to be integrated into various solutions. This article reviews the efficacy of novel PVP-I-based disinfecting solution and HAD wetting agents.
有一半戴隐形眼镜的人使用需要适当护理的可重复使用镜片。不适当的隐形眼镜（CL）护理和使用不充分的消毒解决方案可能导致镜片污染、CL 相关微生物角膜炎和棘阿米巴角膜炎。氧化消毒解决方案，如过氧化氢，比多功能解决方案显示出更高的功效。聚维酮碘（PVP-I），一种用于眼科手术的氧化消毒剂，已被证明是安全有效的。PVP-I 系统，一种在日本开发的 CL 消毒溶液，具有出色的抗菌和抗病毒特性。虽然 CL 不适不会导致角膜炎等视力预后不良的眼部疾病，但 CL 不适仍然会导致镜片脱落，因此需要解决。为了减轻 CL 不适，使用含有表面活性剂和润湿剂的消毒溶液至关重要，这些表面活性剂和润湿剂可以提高镜片表面的润湿性。日本开发了一种含有透明质酸衍生物（HAD）作为润湿剂的 CL 溶液，HAD 作为润湿剂永久附着在镜片表面，以提高镜片表面的润湿性。HAD 有可能整合到各种解决方案中。本文综述了新型基于 PVP-I 的消毒溶液和 HAD 润湿剂的功效。
