Ophtecs Corporation. 5-2-4 Minatojima-Minami-Machi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Ophtecs Corporation. 5-2-4 Minatojima-Minami-Machi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Cont Lens Anterior Eye. 2018 Jun;41(3):277-281. doi: 10.1016/j.clae.2017.12.001. Epub 2017 Dec 8.
Contact lens (CL) wear is a risk factor for the acquisition of microbial keratitis. Accordingly, compliance to manufacturers' recommended hygiene and disinfection procedures are vital to safe (CL) use. In this study we evaluated a novel povidone-iodine (PI) (CL) disinfection system (cleadew, Ophtecs Corporation, Japan) against a range of bacterial, fungal and Acanthamoeba.
Antimicrobial assays were conducted according to ISO 14729 using the recommended strains of bacteria and fungi, with and without the presence of organic soil. Regrowth of bacteria and fungi in the disinfection system was also examined. The activity on biofilms formed from Stenotrophomonas maltophilia and Achromobacter sp. was evaluated. Efficacy against A. castellanii trophozoites and cysts was also investigated.
The PI system gave >4 log kill of all bacteria and fungi following the manufacturer's recommended disinfection and cleaning time of 4h, with or without the presence of organic soil. No regrowth of organisms was found after 14days in the neutralized solution. In the biofilm studies the system resulted in at least a 7 log reduction in viability of bacteria. For Acanthamoeba, >3 log kill of trophozoites and 1.1-2.8 log kill for the cyst stage was obtained.
The PI system effective against a variety of pathogenic microorganisms under a range of test conditions. Strict compliance to recommended CL hygiene procedures is essential for safe CL wear. The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.
隐形眼镜（CL）的佩戴是获得微生物角膜炎的一个危险因素。因此，遵守制造商推荐的卫生和消毒程序对于安全（CL）使用至关重要。在这项研究中，我们评估了一种新的聚维酮碘（PI）（CL）消毒系统（cleadew，Ophtecs Corporation，日本）对一系列细菌、真菌和棘阿米巴的作用。
根据 ISO 14729 进行了抗菌试验，使用了推荐的细菌和真菌菌株，同时存在和不存在有机土壤。还检查了消毒系统中细菌和真菌的再生情况。评估了 Stenotrophomonas maltophilia 和 Achromobacter sp. 形成的生物膜的活性。还研究了对棘阿米巴滋养体和包囊的功效。
PI 系统在制造商推荐的 4 小时消毒和清洁时间内，无论是存在有机土壤还是不存在有机土壤，对所有细菌和真菌的杀灭率均超过 4 对数。在中和溶液中 14 天后未发现微生物再生长。在生物膜研究中，该系统使细菌的存活能力至少降低了 7 对数。对于棘阿米巴，获得了滋养体的>3 对数杀灭和囊阶段的 1.1-2.8 对数杀灭。
PI 系统在多种测试条件下对各种致病微生物有效。严格遵守推荐的 CL 卫生程序对于安全 CL 佩戴至关重要。使用具有广谱抗菌活性的护理系统（如 PI）可能有助于预防潜在威胁视力的微生物角膜炎。
