Strasberg S M, Ilson R G, Bear C E
Can J Physiol Pharmacol. 1986 Oct;64(10):1316-20. doi: 10.1139/y86-222.
Bile salt dependent flow and electrolyte secretion in response to two bile salts were studied in awake rabbits. It was found that sodium glycodeoxycholate had a much greater choleretic and cholioneretic efficiency than sodium taurocholate. The effect of the bile salts on flow and electrolyte secretion was not linear across the range of bile salt secretion rates studied. When amiloride was administered significant decreases in choleretic and cholioneretic efficiencies occurred, but furosemide had no effect. It is concluded that bile salts stimulate electrolyte transport via amiloride inhibitable cellular processes, and that this electrolyte transport is in part responsible for bile salt dependent bile flow.
在清醒兔中研究了两种胆汁盐作用下的胆盐依赖性胆汁流动和电解质分泌。结果发现，甘氨脱氧胆酸钠的利胆和促胆汁电解质分泌效率比牛磺胆酸钠高得多。在所研究的胆汁盐分泌速率范围内，胆汁盐对胆汁流动和电解质分泌的影响并非呈线性关系。给予阿米洛利后，利胆和促胆汁电解质分泌效率显著降低，但呋塞米无此作用。得出的结论是，胆汁盐通过阿米洛利可抑制的细胞过程刺激电解质转运，并且这种电解质转运部分地促成了胆盐依赖性胆汁流动。
