Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
PLoS One. 2023 Nov 29;18(11):e0295071. doi: 10.1371/journal.pone.0295071. eCollection 2023.
This paper aimed to analyze the relationship between baseline prolactin (PRL) levels and live birth rates (LBRs) in patients undergoing embryo transfer who did not have polycystic ovarian syndrome (PCOS) using a retrospective design. Patient(s): A total of 20,877 patients who had undergone IVF/intracytoplasmic sperm injection (ICSI) between December 2014 and December 2019.
We examined the association between PRL concentrations and LBRs using multivariate regression analysis. In addition, a model for nonlinear relationships based on a two-part linear regression was developed.
Following adjustment for confounding factors, multivariate regression analysis confirmed a statistically significant correlation between serum PRL and LBR. Particularly, when blood PRL content was less than 14.8 ng/mL, there exists a positive relation between serum PRL and LBRs. In contrast, once PRL concentrations surpassed the inflection point at 14.8 ng/mL, a meaningful relationship could no longer be inferred between serum PRL and LBR.
Basal serum PRL levels were segmentally connected with LBRs.
本研究采用回顾性设计，旨在分析无多囊卵巢综合征（PCOS）患者胚胎移植时的基础催乳素（PRL）水平与活产率（LBR）之间的关系。
共有 20877 名患者于 2014 年 12 月至 2019 年 12 月期间接受了体外受精/卵胞浆内单精子注射（ICSI）。
我们使用多元回归分析来检验 PRL 浓度与 LBR 之间的关系。此外，还开发了基于两部分线性回归的非线性关系模型。
在调整混杂因素后，多元回归分析证实血清 PRL 与 LBR 之间存在统计学显著相关性。特别是，当血清 PRL 含量低于 14.8ng/ml 时，血清 PRL 与 LBR 之间存在正相关关系。相比之下，一旦 PRL 浓度超过 14.8ng/ml 的拐点，就无法推断血清 PRL 与 LBR 之间存在有意义的关系。
基础血清 PRL 水平与 LBR 呈分段相关。
