Duan Yuwei, Liu Xinyan, Hou Wenhui, Deng Mingfen, Gao Jun, Zhou Canquan, Xu Yanwen
Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
J Obstet Gynaecol Res. 2019 Jul;45(7):1236-1244. doi: 10.1111/jog.13957. Epub 2019 Apr 1.
To investigate whether treated hyperprolactinemia has an impact on pregnancy outcomes in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET).
A retrospective cohort study was conducted on 535 women who underwent IVF/ICSI-ET between January 2012 and December 2016, of which 123 had treated hyperprolactinemia (case group), 369 were matched controls. Besides, 43 remained hyperprolactinemic after treatment consisted of abnormal group. Cumulative live birth rate (CLBR) after one oocyte retrieval cycle was taken as the primary outcome. A time-to-event analysis using Fine and Gray's test was used to compare CLBR between case and control groups.
The median prolactin level was 80.00 ng/mL before dopamine agonist treatment in case group, and it reduced to 14.80 ng/mL after the treatment, similar to the level of control group (15.17 ng/mL, P = 0.316). No significant differences in baseline characteristics were found between case and control groups. The CLBR after one oocyte retrieval cycle were 69.1% (85/123) and 66.4% (245/369) in the case group and control group, respectively (P = 0.580). No significant differences were found between case and control groups in perinatal outcomes. Pregnancy and perinatal outcomes of abnormal group were similar to those of case and control groups.
Impact of treated hyperprolactinemia on CLBR and perinatal outcomes in IVF-ET was not evident.
探讨治疗后的高催乳素血症对体外受精/卵胞浆内单精子注射-胚胎移植（IVF/ICSI-ET）妊娠结局的影响。
对2012年1月至2016年12月期间接受IVF/ICSI-ET的535例女性进行回顾性队列研究，其中123例患有治疗后的高催乳素血症（病例组），369例为匹配对照组。此外，43例治疗后仍为高催乳素血症者组成异常组。将一个取卵周期后的累积活产率（CLBR）作为主要结局。采用Fine和Gray检验进行事件发生时间分析，比较病例组和对照组的CLBR。
病例组多巴胺激动剂治疗前催乳素水平中位数为80.00 ng/mL，治疗后降至14.80 ng/mL，与对照组水平（15.17 ng/mL）相似（P = 0.316）。病例组和对照组基线特征无显著差异。病例组和对照组一个取卵周期后的CLBR分别为69.1%（85/123）和66.4%（245/369）（P = 0.580）。病例组和对照组围产期结局无显著差异。异常组的妊娠和围产期结局与病例组和对照组相似。
治疗后的高催乳素血症对IVF-ET的CLBR和围产期结局的影响不明显。
