Archimbaud E, Coiffier B, Bryon P A, Vasselon C, Brizard C P, Viala J J
Cancer. 1987 Jan 15;59(2):208-12. doi: 10.1002/1097-0142(19870115)59:2<208::aid-cncr2820590205>3.0.co;2-7.
In order to identify prognostic factors in angioimmunoblastic lymphadenopathy (AIL), 30 directly diagnosed patients were prospectively followed for more than 42 months. Age and sex distribution, clinical and laboratory findings and evolution were not different from previously reported series. Median duration of survival was 24 months. Parameters associated with a longer survival in our series were localized adenopathies (P = 0.01) and the achievement of a remission (P less than 0.0001). Features associated with a shorter survival included drug exposure in relation to the onset of the disease (P = 0.02), rash (P less than 0.0001), lymph node eosinophilia (P = 0.03) and elevated serum lactic dehydrogenase (P = 0.03). Drug exposure and rash were, however, significantly dependent (P = 0.02). In addition, lymphopenia, the presence of circulating immune complexes, and the absence of polyclonal hypergammaglobulinemia may indicate a poor prognosis, although the significance level is not achieved in this short series. None of the parameters tested was significantly related to the lymphomatous transformation of AIL, which occurred in four cases. It is concluded that multicentric prospective studies of AIL are necessary in order to better define this disorder, to find prognostic factors, and to optimize therapy.
为了确定血管免疫母细胞性淋巴结病（AIL）的预后因素，对30例直接诊断的患者进行了前瞻性随访，随访时间超过42个月。年龄和性别分布、临床及实验室检查结果和病情演变与先前报道的系列研究并无差异。中位生存期为24个月。在我们的研究系列中，与较长生存期相关的参数为局限性淋巴结病（P = 0.01）和缓解的达成（P＜0.0001）。与较短生存期相关的特征包括疾病发作时的药物暴露（P = 0.02）、皮疹（P＜0.0001）、淋巴结嗜酸性粒细胞增多（P = 0.03）和血清乳酸脱氢酶升高（P = 0.03）。然而，药物暴露和皮疹显著相关（P = 0.02）。此外，淋巴细胞减少、循环免疫复合物的存在以及多克隆高丙种球蛋白血症的缺乏可能预示预后不良，尽管在这个短系列研究中未达到显著水平。所检测的参数均与AIL的淋巴瘤转化无显著相关性，AIL发生淋巴瘤转化的有4例。结论是，有必要对AIL进行多中心前瞻性研究，以便更好地界定这种疾病、找到预后因素并优化治疗。
